Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE TRANSCRIPTION FACTOR CF2 IS A MEDIATOR OF EGF-R-ACTIVATED DORSOVENTRAL PATTERNING IN DROSOPHILA OOGENESIS
Autore:
HSU T; BAGNI C; SUTHERLAND JD; KAFATOS FC;
Indirizzi:
MED UNIV S CAROLINA,CTR MOL & STRUCT BIOL CHARLESTON SC 29425 MED UNIV S CAROLINA,DEPT EXPTL ONCOL CHARLESTON SC 29425 HARVARD UNIV,DEPT MOLEC & CELL BIOL BOSTON MA 02138 EUROPEAN MOLEC BIOL LAB D-69012 HEIDELBERG GERMANY
Titolo Testata:
Genes & development
fascicolo: 11, volume: 10, anno: 1996,
pagine: 1411 - 1421
SICI:
0890-9369(1996)10:11<1411:TTFCIA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
FEMALE STERILE MUTATIONS; DORSAL-VENTRAL AXIS; 2ND CHROMOSOME; EMBRYO; GENE; MELANOGASTER; PROTEIN; LOCALIZATION; POLARITY; CELLS;
Keywords:
DORSOVENTRAL PATTERNING; EGF RECEPTOR SIGNALING; OOGENESIS; TRANSCRIPTION REPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
T. Hsu et al., "THE TRANSCRIPTION FACTOR CF2 IS A MEDIATOR OF EGF-R-ACTIVATED DORSOVENTRAL PATTERNING IN DROSOPHILA OOGENESIS", Genes & development, 10(11), 1996, pp. 1411-1421

Abstract

Establishment of dorsoventral polarity during Drosophila oogenesis requires localized intercellular communication between the follicular cells and the oocyte. This is initiated by the transmission of a ''dorsal signal'' from the oocyte to the anterior dorsal follicle cells by the EGF receptor (EGF-R) pathway and is followed by transmission of a second signal from the ventral follicle cells back to the embryo. We show that the zinc finger transcription factor CF2 participates in these processes. CF2 is suppressed by EGF-R signaling in the anterior dorsalfollicle cells. Altered expression patterns of CF2 result in specificdorsoventral patterning defects in egg chambers and in embryos, as demonstrated phenotypically and with molecular markers. CF2 appears to act as a repressor of dorsal follicle cell fates and specifically as a repressor of the rhomboid gene transcription.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 16:18:34