Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INHIBITION OF CANINE EXOCRINE PANCREATIC-SECRETION BY PEPTIDE YY IS MEDIATED BY PYY-PREFERRING Y2 RECEPTORS
Autore:
TEYSSEN S; GRANDT D; NIEBERGALLROTH E; SCHIMICZEK M; GOEBELL H; EYSSELEIN VE; REEVE JR; SINGER MV;
Indirizzi:
UNIV HEIDELBERG HOSP,DEPT MED GASTROENTEROL 4,THEODOR KUTZER UFER D-68135 MANNHEIM GERMANY UNIV HEIDELBERG HOSP,DEPT MED GASTROENTEROL 4 D-68135 MANNHEIM GERMANY UNIV ESSEN GESAMTHSCH,MED KLIN,DIV GASTROENTEROL W-4300 ESSEN GERMANY UNIV CALIF LOS ANGELES,MED CTR,DEPT GASTROENTEROL TORRANCE CA 90509 UNIV CALIF LOS ANGELES,VET ADM WADSWORTH MED CTR,DEPT MED,CTR ULCER RES & EDUC LOS ANGELES CA 90073
Titolo Testata:
Pancreas
fascicolo: 1, volume: 13, anno: 1996,
pagine: 80 - 88
SICI:
0885-3177(1996)13:1<80:IOCEPB>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIC-ACID SECRETION; NEUROPEPTIDE-Y; STRUCTURAL CHARACTERIZATION; GUT HORMONE; RAT; POLYPEPTIDE; RELEASE; INVITRO; INVIVO; MEAL;
Keywords:
PEPTIDE YY-PYY 3-36; PRO(34)PYY; NEUROPEPTIDE Y; Y2 RECEPTOR; EXOCRINE PANCREATIC SECRETION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
S. Teyssen et al., "INHIBITION OF CANINE EXOCRINE PANCREATIC-SECRETION BY PEPTIDE YY IS MEDIATED BY PYY-PREFERRING Y2 RECEPTORS", Pancreas, 13(1), 1996, pp. 80-88

Abstract

It is still unclear, which receptor subtype, Y1 and/or Y2, mediates the inhibitory action of PYY on exocrine pancreatic secretion. The present study was undertaken to characterize functionally the Y receptor subtype that mediates the inhibition of exocrine pancreatic secretion by peptide YY (PYY). In eight conscious dogs with chronic gastric and pancreatic fistulas, Eve compared the action of intravenous infusion of200 and 400 pmol/kg/h of the Y receptor agonists PYY 1-36, PYY 3-36, PYY 13-36, Pro(34)PYY 1-36, and NPY 1-36 on the pancreatic secretory response to secretin (20.5 pmol/kg/h) and cerulein (29.6 pmol/kg/h). PYY 13-36, Pro(34)PYY 1-36, and NPY 1-36 were also studied by giving a fivefold dose (1,000 and 2,000 pmol/kg/h). PYY 1-36 and the Y2, receptor agonist PYY 3-36 significantly inhibited pancreatic secretory responses to secretin and cerulein, whereas inhibition by NPY 1-36 and the Y2 receptor agonist PYY 13-36 was attainable only at doses of 1,000 and2,000 pmol/kg/h. The Y1 receptor agonist Pro(34)PYY 1-36 was without effect on pancreatic secretion, We conclude that in dogs the inhibition of exocrine pancreatic secretion by PYY is mediated via Y2 receptorsof a PYY-preferring subtype.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 06:07:58