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Titolo:
SUN EXPOSURE, SUNSCREENS, AND SKIN-CANCER PREVENTION - A YEAR-ROUND CONCERN
Autore:
FARMER KC; NAYLOR MF;
Indirizzi:
UNIV OKLAHOMA,HLTH SCI CTR,COLL PHARM,DEPT PHARM PRACTICE,1110 N STONEWALL OKLAHOMA CITY OK 73117 UNIV OKLAHOMA,HLTH SCI CTR,COLL MED,CTR MOLEC MED,DEPT DERMATOL OKLAHOMA CITY OK 00000
Titolo Testata:
The Annals of pharmacotherapy
fascicolo: 6, volume: 30, anno: 1996,
pagine: 662 - 673
SICI:
1060-0280(1996)30:6<662:SESASP>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CUTANEOUS MALIGNANT-MELANOMA; HAIRLESS MOUSE SKIN; ULTRAVIOLET-RADIATION; INFRARED RADIATION; UNITED-STATES; ANIMAL-MODEL; MICE; PHOTODAMAGE; IRRADIATION; SUNLIGHT;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
87
Recensione:
Indirizzi per estratti:
Citazione:
K.C. Farmer e M.F. Naylor, "SUN EXPOSURE, SUNSCREENS, AND SKIN-CANCER PREVENTION - A YEAR-ROUND CONCERN", The Annals of pharmacotherapy, 30(6), 1996, pp. 662-673

Abstract

OBJECTIVE: To review the role of sunlight in skin aging and skin cancer formation, adn to provide guidelines on the use of sunscreens to minimize the adverse effects of sun damage. DATA SOURCES: A MEDLINE search of applicable articles on ultraviolet (UV) radiation, melanoma, sunscreens, and skin cancer, evaluating both human and animal studies. Published and unpublished original research as well as clinical experience were also used. DATA SYNTHESIS: The interaction of UV radiation andskin type plays a central role in melanoma formation. Mortality form melanoma is highest in geographic locations near the equator, where UVintensity is greatest. The incidence of melanomas in light-complectedindividuals (skin types I-III) is several time higher than those withdarker skin types (types IV-VI), even in similar geographic regions. The UVB portion of th spectrum appears to be primarily responsible forskin cancer formation and photoaging, while short wave UVA rays play a significant contributing role. Regular sunscreen use has been shown to reduce the formation of precancerous actinic keratoses (AK) lesionsby 36%. A dose-response relationship has also been found between the amount of sunscreens used and AK formation. CONCLUSIONS: Sunscreens have now been shown to reduce the carcinogenic effects of sunlight in humans. Patients should be advised of the long-term consequences of sun exposure and the benefits of regular sunscreen use.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 11:51:52