Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
IMMUNOLOCALIZATION OF GLYCOPROTEIN A-80 IN PROSTATIC-CARCINOMA AND PROSTATIC INTRAEPITHELIAL NEOPLASIA
Autore:
GOULD VE; DOLJANSKAIA V; GOOCH G; BOSTWICK DG;
Indirizzi:
RUSH MED COLL,DEPT PATHOL,1653 W CONGRESS PKWY CHICAGO IL 60612 ABBOTT LABS N CHICAGO IL 60064 MAYO CLIN ROCHESTER MN 00000
Titolo Testata:
Human pathology
fascicolo: 6, volume: 27, anno: 1996,
pagine: 547 - 552
SICI:
0046-8177(1996)27:6<547:IOGAIP>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUCIN-TYPE GLYCOPROTEIN; MURINE MONOCLONAL-ANTIBODIES; CANCER-ASSOCIATED ANTIGEN; DUCT-ACINAR DYSPLASIA; HUMAN-BREAST-CANCER; HUMAN MAMMARY; MAB A-80; IMMUNOHISTOCHEMICAL ANALYSIS; CARCINOEMBRYONIC ANTIGEN; DIFFERENTIATION ANTIGENS;
Keywords:
PROSTATE; PROSTATIC CARCINOMA; PROSTATIC INTRAEPITHELIAL NEOPLASIA; MUCINS; GLYCOPROTEINS; A-80; IMMUNOHISTOCHEMISTRY; PROGNOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
66
Recensione:
Indirizzi per estratti:
Citazione:
V.E. Gould et al., "IMMUNOLOCALIZATION OF GLYCOPROTEIN A-80 IN PROSTATIC-CARCINOMA AND PROSTATIC INTRAEPITHELIAL NEOPLASIA", Human pathology, 27(6), 1996, pp. 547-552

Abstract

A-80 is a mucin-like glycoprotein associated with exocrine differentiation that shows little or no expression in normal exocrine cells and typical adenomas, but is upregulated in dysplasia and adenocarcinoma of certain organs. Its expression has not been systematically examined in prostatic adenocarcinoma and its putative precursor, prostatic intraepithelial neoplasia (PIN). The authors applied a mouse monoclonal antibody against A-80 in paraffin-embedded sections from 103 cases of prostatic carcinoma, 26 cases of nodular hyperplasia, 7 autopsy samples from normal young adult prostates, and 12 fetal prostates. All but onecancer reacted, although expression was heterogeneous; 75 of 103 stained extensively (>3+ on a 0 to 5+ scale) and strongly. Staining extentand intensity were independent of tumor grade, and tended to be strong even when focal. Seventy-seven of 84 fod (92%) of high-grade PIN and38 of 52 loci (73%) of low-grade PIN stained for A-80; reactions weremost extensive and intense in high grade PIN. Only 5 of 26 cases (19%) of hyperplasia reacted, and this consisted of weak to moderate staining in sporadic cells; the remainder were negative. Normal adult prostatic epithelium did not express A-80 except for weak and inconsistent staining in foci of inflammation and infarction; atrophic glands were negative. Fetal prostate showed focally strong reactivity. These results indicate that A-80 is selectively expressed in most cases of intraepithelial neoplasia and prostate cancer, but is usually absent in benign and hyperplastic epithelium. The upregulation of glycoprotein A-80 in PIN and adenocarcinoma parallels observations in other organs, suchas the breast and colon, suggesting that this is a significant oncodevelopmental molecule with potential clinical applications. Copyright (C) 1996 by W.B. Saunders Company

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:40:06