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Titolo:
MUSCARINIC ACETYLCHOLINE-RECEPTOR SUBTYPE MESSENGER-RNAS IN THE HUMANAND RAT VESTIBULAR PERIPHERY
Autore:
WACKYM PA; CHEN CT; ISHIYAMA A; PETTIS RM; LOPEZ IA; HOFFMAN L;
Indirizzi:
MT SINAI SCH MED,DEPT OTOLARYNGOL,MOLEC BIOL LAB,BOX 1189,5TH AVE & 100TH ST NEW YORK NY 10029 UNIV CALIF LOS ANGELES,SCH MED,DIV HEAD & NECK SURG LOS ANGELES CA 90024
Titolo Testata:
Cell biology international
fascicolo: 3, volume: 20, anno: 1996,
pagine: 187 - 192
SICI:
1065-6995(1996)20:3<187:MASMIT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
MODULATION; EPITHELIA; COCHLEAR; SYSTEM; FROG;
Keywords:
GENE EXPRESSION; MUSCARINIC ACETYLCHOLINE RECEPTOR; NEUROCHEMISTRY; RT-PCR; VESTIBULAR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
P.A. Wackym et al., "MUSCARINIC ACETYLCHOLINE-RECEPTOR SUBTYPE MESSENGER-RNAS IN THE HUMANAND RAT VESTIBULAR PERIPHERY", Cell biology international, 20(3), 1996, pp. 187-192

Abstract

The expression of the five muscarinic acetylcholine receptor (mAChR) subtypes (m1-m5) in the vestibular end-organs and in the primary afferent vestibular ganglia of the human and rat was studied using RT-PCR from the two tissue populations from both species. In the human, although all five mAChR subtypes were expressed in brain, only the mt, m2, and m5 mAChR subtypes were amplified from both the vestibular ganglia and the vestibular end-organs, while in the rat, all five mAChR subtypes were expressed. These data suggest that the efferent cholinergic axo-dendritic and axe-somatic synapses have a muscarinic component and that there are pharmacologic implications for patients with vestibular dysfunction. (C) 1996 Academic Press Limited

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 10:45:30