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Titolo:
SYNTHESIS OF FLAVONE-8-CARBOXYLIC ACID ANALOGS AS POTENTIAL ANTITUMORAGENTS
Autore:
CUTLER SJ; ELKABBANI FM; KEANE C; FISHERSHORE SL; MCCABE FL; JOHNSON RK; BLANTON CD;
Indirizzi:
UNIV GEORGIA,COLL PHARM,DEPT MED CHEM ATHENS GA 30602 UNIV GEORGIA,COLL PHARM,DEPT MED CHEM ATHENS GA 30602 SMITHKLINE BEECHAM PHARMACEUT,DEPT BIOMOLEC DISCOVERY KING OF PRUSSIAPA 19406
Titolo Testata:
European journal of medicinal chemistry
fascicolo: 5, volume: 28, anno: 1993,
pagine: 407 - 414
SICI:
0223-5234(1993)28:5<407:SOFAAA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLAVONE ACETIC-ACID; PHASE-II TRIALS; 9-OXO-9H-XANTHENE-4-ACETIC ACID; NATURAL-PRODUCTS; BLOOD-FLOW; NSC-347512; TUMORS; COLON; MICE; DERIVATIVES;
Keywords:
FLAVONE-8-ACETIC ACID; FLAVONE-8-CARBOXYLIC ACIDS; FURAN O-AMINONITRILES; ANTITUMOR; MELANOMA; ANTI-HIV;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
S.J. Cutler et al., "SYNTHESIS OF FLAVONE-8-CARBOXYLIC ACID ANALOGS AS POTENTIAL ANTITUMORAGENTS", European journal of medicinal chemistry, 28(5), 1993, pp. 407-414

Abstract

Furan o-aminonitriles may be utilized as precursors in the synthesis of flavone-8-carboxylic acids. Some results from in vivo evaluation against P388 leukemia, colon carcinoma 38, and B16 melanoma models suggest that selected examples of the acids are potentially as effective asthe antitumor compound, flavone acetic acid. The flavone-8-carboxylicacids did not exhibit significant activity against an in vitro HIV screen or an in vitro antitumor screen consisting of a cell panel of 60 lines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 22:00:43