Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ENHANCED EFFECTS OF CO-ADMINISTERED DEXAMETHASONE AND DICLOFENAC ON INFLAMMATORY PAIN PROCESSING AND ASSOCIATED SPINAL C-FOS EXPRESSION IN THE RAT
Autore:
BURITOVA J; HONORE P; CHAPMAN V; BESSON JM;
Indirizzi:
INSERM U161,UNITE RECH PHYSIOPHARMACOL SYST NERVEUX,2 RUE ALESIA F-75014 PARIS FRANCE EPHE F-75014 PARIS FRANCE
Titolo Testata:
Pain
fascicolo: 3, volume: 64, anno: 1996,
pagine: 559 - 568
SICI:
0304-3959(1996)64:3<559:EEOCDA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; ASPIRIN-LIKE DRUGS; PROSTAGLANDIN BIOSYNTHESIS; GENE-EXPRESSION; MESSENGER-RNA; INHIBITION; PHOSPHOLIPASE-A2; CYCLOOXYGENASE; HYPERALGESIA; NEURONS;
Keywords:
CARRAGEENAN; C-FOS; DEXAMETHASONE; DICLOFENAC; INFLAMMATORY PAIN; SPINAL CORD; (RAT);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
70
Recensione:
Indirizzi per estratti:
Citazione:
J. Buritova et al., "ENHANCED EFFECTS OF CO-ADMINISTERED DEXAMETHASONE AND DICLOFENAC ON INFLAMMATORY PAIN PROCESSING AND ASSOCIATED SPINAL C-FOS EXPRESSION IN THE RAT", Pain, 64(3), 1996, pp. 559-568

Abstract

This Study determines the effects of dexamethasone versus co-administered dexamethasone and diclofenac, on carrageenan-evoked spinal c-Fos expression and peripheral oedema in the freely moving rat. Drugs were administered intravenously 25 min before intraplantar injection of carrageenan (6 mg/150 mu l of saline). Three hours later the number of spinal c-Fos-LI neurones and peripheral oedema were assessed. The total number of control carrageenan-evoked c-Fos-LI neurones in the lumbar spinal cord was 121 +/- 5 labelled neurones per section, segments L4-L5, which were predominantly located in the superficial and deep laminae(41 +/- 3% and 40 +/- 2% of the total number of c-Fos-LI neurones persection, respectively) of the dorsal horn of the spinal cord. Pre-administered dexamethasone (0.05, 0.10 and 0.50 mg/kg i.v.) dose-dependently reduced the total number of c-Fos-LI neurones (30 +/- 4%, 52 +/- 3% and 58 +/- 2% reduction, respectively), with effects of the higher doses being strongest on the deep laminae c-Fos-LI neurones. The effects of dexamethasone on the total number of c-Fos-LI neurones and the peripheral oedema were positively correlated. Go-administration of low doses of dexamethasone and diclofenac (0.025 + 1.5 mg/kg i.v. respectively), which had negligible effects when administered separately, greatly reduced both the total number of carrageenan-evoked c-Fos-LI neurones (61 +/- 5% reduction as compared to control value) and the peripheral oedema (80 +/- 8% and 60 +/- 5% reduction for ankle and paw oedema,respectively). The attenuation by co-administered dexamethasone and diclofenac, of both c-Fos expression and the peripheral oedema, was significantly greater than the effect of dexamethasone alone (P < 0.001 for both) and diclofenac alone (P < 0.001 for both). Our study illustrates enhanced attenuating effects of co-administered dexamethasone and diclofenac on both inflammatory oedema and the associated spinal expression of c-Fos, an indicator of nociceptive transmission at the spinallevel. The apparent interactions between the mechanisms of action of NSAIDs and steroids suggest that co-therapy may produce beneficial inflammatory and pain relief in the absence of excessive side effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 20:18:06