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Titolo:
THE CONTRIBUTION OF GABA(B) RECEPTOR-MEDIATED EVENTS TO INFLAMMATORY PAIN PROCESSING - CARRAGEENAN EDEMA AND ASSOCIATED SPINAL C-FOS EXPRESSION IN THE RAT
Autore:
BURITOVA J; CHAPMAN V; HONORE P; BESSON JM;
Indirizzi:
INSERM U161,LAB PHYSIOPHARMACOL SYST NERVEUX,2 RUE ALESIA F-75014 PARIS FRANCE EPHE F-75014 PARIS FRANCE
Titolo Testata:
Neuroscience
fascicolo: 2, volume: 73, anno: 1996,
pagine: 487 - 496
SICI:
0306-4522(1996)73:2<487:TCOGRE>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY AFFERENT TERMINALS; CENTRAL-NERVOUS-SYSTEM; DORSAL HORN NEURONS; SUBSTANTIA-GELATINOSA; TRANSGANGLIONIC TRANSPORT; IMMUNOREACTIVE TERMINALS; CORD NEURONS; BACLOFEN; HYPERALGESIA; ORGANIZATION;
Keywords:
INFLAMMATORY PAIN; CARRAGEENAN; BACLOFEN; C-FOS; SPINAL CORD; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
78
Recensione:
Indirizzi per estratti:
Citazione:
J. Buritova et al., "THE CONTRIBUTION OF GABA(B) RECEPTOR-MEDIATED EVENTS TO INFLAMMATORY PAIN PROCESSING - CARRAGEENAN EDEMA AND ASSOCIATED SPINAL C-FOS EXPRESSION IN THE RAT", Neuroscience, 73(2), 1996, pp. 487-496

Abstract

In this pharmacological study we have assessed the effect of baclofen, a selective GABA(B) receptor agonist, on spinal expression of the immediate early gene c-Fos and the peripheral oedema evoked by a prolonged peripheral inflammation due to intraplantar carrageenan. Baclofen was administered intravenously 30 min before intraplantar injection of carrageenan in freely moving rats. Three hours after carrageenan the number of spinal c-Fos protein-like immunoreactive neurons and peripheral (ankle and paw) oedema were assessed. For the two series of experiments the total number of control carrageenan-evoked c-Fos protein-likeimmunoreactive neurons in segments L4-L5 of the spinal cord was 176 +/- 6 and 177 +/- 9 c-Fos protein-like immunoreactive neurons per section, for carrageenan control with intravenous and intraplantar saline, respectively. c-Fos protein-like immunoreactive neurons were predominantly located in laminae I-II and V-VI of the dorsal horn of the spinalcord in carrageenan controls receiving intravenous (68 +/- 3 and 69 +/- 2 c-Fos protein-like immunoreactive neurons, respectively) and intraplantar (62 +/- 4 and 71 +/- 5 c-Fos protein-like immunoreactive neurons, respectively) saline. Pre-administered systemic baclofen (0.05, 1.5 and 3 mg/kg i.v.) hose dependently reduced the total number of c-Fos protein-like immunoreactive neurons (81 +/- 3, 66 +/- 4 and 49 +/- 4% of control total number of c-Fos protein-like immunoreactive neurons, respectively), with strongest effects on the number of deep (74 +/- 3, 60 +/- 3 and 43 +/- 4% of control, respectively) as compared with superficial (90 +/- 4, 77 +/- 5 and 59 +/- 5% of control, respectively)c-Fos protein like immunoreactive neurons: The effects of systemic baclofen on the carrageenan-induced spinal c-Fos expression and both thepaw and ankle oedema were positively correlated (r = 0.479, P < 0.05 and r = 0.733, P < 0.001, respectively). Intraplantar baclofen (50 and100 mu g in 50 mu l of saline), simultaneously injected with intraplantar carrageenan, did not significantly influence carrageenan-evoked spinal c-Fos expression or ankle oedema. Despite the fact that the highest dose of intraplantar baclofen significantly reduced paw oedema (23+/- 3% reduction of control paw oedema), our results are clearly in favour of a spinal site of action of systemic baclofen. Copyright (C) 1996 IBRO.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 20:37:44