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Titolo:
TROPHOBLAST MIGRATION DURING HUMAN PLACENTAL IMPLANTATION
Autore:
BURROWS TD; KING A; LOKE YW;
Indirizzi:
UNIV CAMBRIDGE,DEPT PATHOL,RES GRP HUMAN REPROD IMMUNOBIOL,TENNIS COURT RD CAMBRIDGE CB2 1QP ENGLAND
Titolo Testata:
Human reproduction update
fascicolo: 4, volume: 2, anno: 1996,
pagine: 307 - 321
SICI:
1355-4786(1996)2:4<307:TMDHPI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOMETRIAL STROMAL CELLS; MATRIX-DEGRADING METALLOPROTEINASES; PLASMINOGEN-ACTIVATOR PRODUCTION; INTEGRIN-LIGAND INTERACTIONS; EPIDERMAL GROWTH-FACTOR; FOCAL ADHESION KINASE; EXTRACELLULAR-MATRIX; SIGNAL-TRANSDUCTION; 1ST TRIMESTER; TERMINAL DIFFERENTIATION;
Keywords:
EXTRACELLULAR MATRIX; INTEGRINS; METALLOPROTEINASES; TROPHOBLAST;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
128
Recensione:
Indirizzi per estratti:
Citazione:
T.D. Burrows et al., "TROPHOBLAST MIGRATION DURING HUMAN PLACENTAL IMPLANTATION", Human reproduction update, 2(4), 1996, pp. 307-321

Abstract

During the process of implantation in humans, fetal trophoblast cellsinvade and migrate into the maternal decidua, During this migration, trophoblast cells destroy the wall of the maternal spiral arteries, converting them from muscular vessels into flaccid sinusoidal sacs, Thisvascular transformation is important to ensure an adequate blood supply to the feto-placental unit, Both cell-cell and cell-matrix interactions are important for trophoblast invasion of the decidual stroma anddecidual spiral arteries. Cell-matrix adhesions are mediated by specific receptors, mostly belonging to the family of integrins. Signals transduced to the cells from the matrix via integrins could play a pivotal role in the control of cellular behaviour and gene expression, suchas metalloproteinases that facilitate matrix degradation and tissue remodelling, This review focuses on the role of integrins and extracellular matrix in trophoblast cell migration, trophoblast invasion of thedecidual spiral arteries and matrix degradation by trophoblast duringimplantation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:16:12