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Titolo:
EFFECTS OF ALPHA-2-ADRENOCEPTOR AGONISTS ON INDUCED DIURESIS IN RATS
Autore:
SHOCKLEY DC; WADE LH; WILLIAMSJOHNSON MM;
Indirizzi:
MEHARRY MED COLL,DEPT PHARMACOL NASHVILLE TN 37208 ALVIN C YORK VET ADM MED CTR,LAB SERV MURFREESBORO TN 37130
Titolo Testata:
Life sciences
fascicolo: 3, volume: 53, anno: 1993,
pagine: 251 - 259
SICI:
0024-3205(1993)53:3<251:EOAAOI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-ADRENERGIC STIMULATION; RENAL WATER EXCRETION; MECHANISM; CLONIDINE; GUANABENZ; NOREPINEPHRINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
D.C. Shockley et al., "EFFECTS OF ALPHA-2-ADRENOCEPTOR AGONISTS ON INDUCED DIURESIS IN RATS", Life sciences, 53(3), 1993, pp. 251-259

Abstract

The alpha-2 adrenoceptor agonists, clonidine, guanabenz, and guanfacine, injected subcutaneously produced a dose-related diuresis. The maximal effect occurred at 2h after administration of clonidine 192 mug/kgor 960 mug/kg of guanabenz and guanfacine. The alpha-2 antagonist, yohimbine, in doses of 1-8 mg/kg administered prior to the agonists caused a dose- dependent decrease in urine output. The action of the threeagonists at alpha-2 adrenoceptors was supported by the observation that the alpha-1 adrenoceptor agonist, prazosin (0.61-2.5 mg/kg), administered prior to each agonist caused an inconsistent decrease in the elevated urinary output caused by clonidine, guanabenz and guanfacine. These results indicate that stimulation of alpha-2 adrenoceptors causesdiuresis in the rat.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 03:05:05