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Titolo:
GROWTH-CHARACTERISTICS OF CELLS CULTURED FROM 2 MURINE MODELS OF POLYCYSTIC-KIDNEY-DISEASE
Autore:
RANKIN CA; ZIEMER DM; MASER RL; FOO I; CALVET JP;
Indirizzi:
UNIV KANSAS,MED CTR,DEPT BIOCHEM & MOLEC BIOL KANSAS CITY KS 66160
Titolo Testata:
In vitro cellular & developmental biology. Animal
fascicolo: 2, volume: 32, anno: 1996,
pagine: 100 - 106
SICI:
1071-2690(1996)32:2<100:GOCCF2>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTOONCOGENE EXPRESSION; CPK MOUSE; CYSTIC-DISEASE; EARLY REGION; RENAL CYSTS; SV40; TRANSFORMATION; NEOPLASIA; EPITHELIA; GENE;
Keywords:
POLYCYSTIC KIDNEY DISEASE; PROLIFERATION; MURINE MODELS OF PKD; GROWTH RATES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
C.A. Rankin et al., "GROWTH-CHARACTERISTICS OF CELLS CULTURED FROM 2 MURINE MODELS OF POLYCYSTIC-KIDNEY-DISEASE", In vitro cellular & developmental biology. Animal, 32(2), 1996, pp. 100-106

Abstract

Polycystic kidney disease (PKD) is characterized by multiple renal cysts that are lined by epithelium and filled with fluid. PKD may resultfrom one of a number of factors, either inherited or environmental. In this study, we have compared two mouse models in which PKD results from a genetic cause. In the C57BL/6J-cpk model, the mutated gene is unknown. In the other model, an SV40 large T antigen transgene causes renal cysts. We examined cultured cells from the kidneys of these mouse models, comparing growth characteristics, Although several features ofPKD lead one to expect that the epithelial cells lining the cysts would have an increased rate of proliferation in culture, we found that they did not. The implications of these findings are discussed.

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Documento generato il 20/09/20 alle ore 04:39:42