Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INTERACTION OF ETHYLAZINPHOS WITH THE PHYSICAL ORGANIZATION OF MODEL AND NATIVE MEMBRANES
Autore:
VIDEIRA RA; ANTUNESMADEIRA MD; MADEIRA VMC;
Indirizzi:
DEPT ZOOL,CTR NEUROCIENCIAS P-3049 COIMBRA PORTUGAL DEPT ZOOL,CTR NEUROCIENCIAS P-3049 COIMBRA PORTUGAL
Titolo Testata:
Biochimica et biophysica acta. Biomembranes
fascicolo: 1, volume: 1281, anno: 1996,
pagine: 65 - 72
SICI:
0005-2736(1996)1281:1<65:IOEWTP>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
O,O,S-TRIMETHYL PHOSPHOROTHIOATE; PHASE-EQUILIBRIA; FLUIDITY; DDT; DIPHENYLHEXATRIENE; MECHANISMS; PARATHION; TOXICITY; MIXTURES; LECITHIN;
Keywords:
ETHYLAZINPHOS; CHOLESTEROL; FLUORESCENT PROBE; MEMBRANE ORGANIZATION; PARTITION COEFFICIENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
R.A. Videira et al., "INTERACTION OF ETHYLAZINPHOS WITH THE PHYSICAL ORGANIZATION OF MODEL AND NATIVE MEMBRANES", Biochimica et biophysica acta. Biomembranes, 1281(1), 1996, pp. 65-72

Abstract

The interaction of ethylazinphos with the physical organization of model and native membranes was investigated by means of fluorescence polarization of 1,6-diphenyl-1,3,5-hexatriene (DPH) and of its propionic acid derivative (DPH-PA). Ethylazinphos shifts the phase transition midpoint to lower temperature values and broadens the phase transition profile of bilayers reconstituted with dimyristoyl-, dipalmitoyl- and distearoylphosphatidylcholines (DMPC, DPPC, DSPC), as detected by DPH and DPH-PA. Additionally, both probes detect significant effects of ethylazinphos in the fluid phase of the above lipid bilayers. The insecticide perturbations are more pronounced in bilayers of short-chain lipids, e.g., DMPC, in correlation with the higher partition in these membranes. On the other hand, the insecticide increases to some extent theordering promoted by cholesterol in the fluid phase of DMPC, but highcholesterol concentrations (greater than or equal to 30 mol%) almost prevent insecticide interaction, as revealed by DPH and DPH-PA. In agreement with the results in models of synthetic lipids, the increase ofintrinsic cholesterol in fluid native membranes depresses the partition values of ethylazinphos and consequently its effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 15:58:41