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Titolo:
MOTHER-TO-CHILD TRANSMISSION OF HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-I AND TYPE-II (HTLV-I II) IN GABON, A PROSPECTIVE FOLLOW-UP OF 4 YEARS/
Autore:
NYAMBI PN; VILLE Y; LOUWAGIE J; BEDJABAGA I; GLOWACZOWER E; PEETERS M; KEROUEDAN D; DAZZA MC; LAROUZE B; VANDERGROEN G; DELAPORTE E;
Indirizzi:
INST TROP MED,DIV MICROBIOL,DEPT INFECT & IMMUN,NATL STRAAT 155 B-2000 ANTWERP BELGIUM CTR INT RECH MED FRANCEVILLE GABON CTR HOSP FRANCEVILLE GABON ORSTOM,RETROVIRUS LAB F-34032 MONTPELLIER FRANCE INSERM,U13 IMEA PARIS FRANCE
Titolo Testata:
Journal of acquired immune deficiency syndromes and human retrovirology
fascicolo: 2, volume: 12, anno: 1996,
pagine: 187 - 192
SICI:
1077-9450(1996)12:2<187:MTOHTL>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEUKEMIA-VIRUS; HORIZONTAL TRANSMISSION; EQUATORIAL AFRICA; CARRIER MOTHERS; COMMON MARMOSET; RISK FACTOR; INFECTION; MILK; AMPLIFICATION; ANTIBODIES;
Keywords:
HTLV; MOTHER-TO-CHILD TRANSMISSION; PROSPECTIVE COHORT; SIBLING; FAMILIAL CLUSTERING; POLYMERASE CHAIN REACTION; WESTERN BLOT; AMNIOTIC FLUID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
P.N. Nyambi et al., "MOTHER-TO-CHILD TRANSMISSION OF HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-I AND TYPE-II (HTLV-I II) IN GABON, A PROSPECTIVE FOLLOW-UP OF 4 YEARS/", Journal of acquired immune deficiency syndromes and human retrovirology, 12(2), 1996, pp. 187-192

Abstract

For 4 years, we determined the mode and risk of mother-to-child transmission of HTLV-I in a prospective cohort of 34 children born to seropositive mothers in Franceville, Gabon. We also determined the prevalence of antibodies to HTLV-I/II in siblings born to seropositive mothers. Antibodies to HTLV-I/II were detected by Western blot, and the proviral DNA was detected by the polymerase chain reaction (PCR). The risk of seroconversion to anti-HTLV-I for the 4 years of follow-up was 17.5%. Anti-HTLV-I/lI and proviral DNA were only detected after age 18 months. We observed a seroprevalence. rate of 15% among the siblings bornto HTLV-I/II seropositive mothers. Furthermore, we report a case of mother-to-child transmission of HTLV-II infection in a population of HTLV-II-infected pregnant women that is emerging in Gabon. The lack of detection of HTLV-I/II proviral DNA in cord blood and amniotic fluid and, furthermore, the late seroconversion observed in the children indirectly indicate that mother-to-child transmission occurred postnatally,probably through breast milk.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 10:05:24