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Titolo:
[H-3] NALOXONE BINDING IN THE HUMAN BRAIN - ALCOHOLISM AND THE TAQI-AD-2 DOPAMINE-RECEPTOR POLYMORPHISM
Autore:
RITCHIE T; NOBLE EP;
Indirizzi:
UNIV CALIF LOS ANGELES,DEPT PSYCHIAT & BEHAV SCI,ALCOHOL RES CTR LOS ANGELES CA 90024 UNIV CALIF LOS ANGELES,DEPT PSYCHIAT & BEHAV SCI,ALCOHOL RES CTR LOS ANGELES CA 90024 UNIV CALIF LOS ANGELES,BRAIN RES INST LOS ANGELES CA 90024 UNIV CALIF LOS ANGELES,INST NEUROPSYCHIAT LOS ANGELES CA 90024
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 718, anno: 1996,
pagine: 193 - 197
SICI:
0006-8993(1996)718:1-2<193:[NBITH>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT STRIATAL NEURONS; GENE-EXPRESSION; OPIATE RECEPTORS; MESSENGER-RNAS; ETHANOL ALTERS; OPIOID PEPTIDE; ENKEPHALIN; MORPHINE; PREPROENKEPHALIN; ASSOCIATION;
Keywords:
DOPAMINE D-2 RECEPTOR GENE; ALCOHOLISM NALOXONE; OPIATE RECEPTOR; FRONTAL CORTEX; CAUDATE NUCLEUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
T. Ritchie e E.P. Noble, "[H-3] NALOXONE BINDING IN THE HUMAN BRAIN - ALCOHOLISM AND THE TAQI-AD-2 DOPAMINE-RECEPTOR POLYMORPHISM", Brain research, 718(1-2), 1996, pp. 193-197

Abstract

[H-3]Naloxone binding was measured in frontal gray cortex, caudate nucleus, amygdala, hippocampus and cerebellar cortex obtained post mortem from human alcoholic and nonalcoholic subjects. Binding was found tobe higher in alcoholics than in nonalcoholics for all of the brain regions examined, with a significant difference in the frontal cortex. When subjects were grouped by the presence or absence of the Al (minor)allele of the D-2 dopamine receptor gene, [H-3]naloxone binding was lower in all brain regions examined of subjects with the Al allele thanin those without this allele, with a significant difference in the caudate nucleus. These findings suggest that one of the consequences of chronic alcohol exposure in humans is an enhancement of the brain opiate receptor system. However, the decreased [H-3]naloxone binding observed in subjects with the Al allele may be a compensatory response to their decreased dopaminergic modulation of opiate receptor activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 19:12:05