Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CORRELATES AND CONSEQUENCES OF DIFFUSE ATHEROSCLEROSIS IN MEN WITH CORONARY HEART-DISEASE
Autore:
WILT TJ; RUBINS HB; COLLINS D; OCONNOR TZ; RUTAN GH; ROBINS SJ;
Indirizzi:
VET AFFAIRS MED CTR,SECT GEN INTERNAL MED 1110,1 VET DR MINNEAPOLIS MN 55417 VET AFFAIRS MED CTR,DEPT MED MINNEAPOLIS MN 55417 UNIV MINNESOTA,SCH MED MINNEAPOLIS MN 55455 VET AFFAIRS CONNECTICUT HLTH CARE SYST W HAVEN,VET AFFAIRS COOPERAT STUDIES PROGRAM COORDINATING W HAVEN CT 00000 VET AFFAIRS MED CTR,SECT GEN MED MEMPHIS TN 00000 VET AFFAIRS MED CTR,DEPT MED MEMPHIS TN 00000 UNIV TENNESSEE,SCH MED MEMPHIS TN 00000 VET AFFAIRS MED CTR,SECT LIPID METAB BOSTON MA 00000 VET AFFAIRS MED CTR,DEPT MED BOSTON MA 00000 BOSTON UNIV,SCH MED BOSTON MA 02118
Titolo Testata:
Archives of internal medicine
fascicolo: 11, volume: 156, anno: 1996,
pagine: 1181 - 1188
SICI:
0003-9926(1996)156:11<1181:CACODA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENSITY-LIPOPROTEIN CHOLESTEROL; RISK-FACTORS; MYOCARDIAL-INFARCTION; BLOOD-PRESSURE; ARTERY DISEASE; MORTALITY; SMOKING; SURVIVAL; INDEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
T.J. Wilt et al., "CORRELATES AND CONSEQUENCES OF DIFFUSE ATHEROSCLEROSIS IN MEN WITH CORONARY HEART-DISEASE", Archives of internal medicine, 156(11), 1996, pp. 1181-1188

Abstract

Background: Peripheral atherosclerosis is a strong and independent predictor of mortality even in patients with known coronary heart disease. However, the prevalence, correlates, and potential adverse effects on quality of life associated with combined coronary heart disease andclinically evident cerebrovascular or lower-extremity atherosclerosisare not known. Identification of patients with ''diffuse atherosclerosis'' may enhance treatment of modifiable risk factors and alter therapeutic strategies. Methods: We conducted a cross-sectional analysis of2531 men younger than 73 years with coronary heart disease, low-density lipoprotein cholesterol levels of 3.62 mmol/L (140 mg/dL) or less, and high-density lipoprotein cholesterol level of 1.03 mmol/L (40 mg/dL) or less who were participating in Department of Veterans Affairs Cooperative Study 363 (the Veterans Affairs High-Density Lipoprotein Intervention Trial. Baseline demographic, medication, comorbidity, and atherosclerotic risk factor data were asset;sed by means of a standardized questionnaire. All plasma lipid levels were determined after a 12-hour fast by a central standardized lipid laboratory. Health status wasdetermined by baseline reported symptoms, medical comorbidities, and the Psychological General Well-being Index. Clinically evident diffuseatherosclerosis was defined as a documented history of lower-extremity atherosclerosis or cerebrovascular disease.Results: The mean age of all participants was 63.5 years. The mean plasma lipid values were as follows: total cholesterol, 4,52 mmol/L (174.6 mg/dL); high-density lipoprotein cholesterol, 0.81 mmol/L (31.5 mg/dL); low-density lipoprotein cholesterol, 2.88 mmol/L (111.2 mg/dL); and triglycerides, 1.81 mmol/L (160.6 mg/dL). Diffuse atherosclerosis was present in 525 (21%). Lower-extremity atherosclerosis was reported in 10%, while cerebrovascular disease was present in 13%. After controlling for other variables,the following factors were associated with the presence of diffuse atherosclerosis: increased age, being unmarried, being retired, having less than a high school education, increased alcohol use, hypertension,cigarette smoking, and diabetes. There was no association between lipid levels and the presence of diffuse atherosclerosis. After adjustment for age, race, and comorbidities, men with diffuse disease still hada reduced quality of life compared with men without diffuse atherosclerosis, as defined by having a greater number of clinical symptoms, lower psychological well-being scores, and more advanced or complicated coronary heart disease. Conclusions: Clinically evident diffuse atherosclerosis is common in men with coronary heart disease and low levels of high-density lipoprotein cholesterol. Because diffuse atherosclerosis is associated with a reduced quality of life and several modifiablerisk factors, early detection and aggressive risk factor interventionappear justified.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:21:08