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Titolo:
TREATMENT WITH AEROSOLIZED AMILORIDE IN C YSTIC-FIBROSIS
Autore:
LINDEMANN H;
Indirizzi:
UNIV GIESSEN,KINDERKLIN,FUNKTIONSBEREICH PADIATR PNEUMOL & ALLERGOL,FEULGENSTR 12 W-6300 GIESSEN GERMANY
Titolo Testata:
Monatsschrift fur Kinderheilkunde
fascicolo: 5, volume: 141, anno: 1993,
pagine: 392 - 394
SICI:
0026-9298(1993)141:5<392:TWAAIC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
GER
Keywords:
EXCESSIVE SODIUM ABSORPTION; TRANSEPITHELIAL POTENTIAL DIFFERENCE; SODIUM-BLOCKING AMILORIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
H. Lindemann, "TREATMENT WITH AEROSOLIZED AMILORIDE IN C YSTIC-FIBROSIS", Monatsschrift fur Kinderheilkunde, 141(5), 1993, pp. 392-394

Abstract

The defective regulation of the secretory chloride channel and the accelerated rate of sodium absorption in the airway epithelia of patients with cystic fibrosis (CF) contribute to the dehydration of airway secretions which is responsible for secondary damage in the respiratory tract. The sodium-blocker amiloride inhibits sodium absorption depending on the dosage of the drug. This effect is documented by means of measuring transepithelial potential difference which is decreased following to inhalative amiloride administration in CF patients. Clinical long term efficiency has been shown to be probable, but has to be confirmed. Investigation in this field is difficult, because there are some other important factors which influence viscosity of mucus. The use ofamiloride can best be evaluated, if it is given immediately after birth. However, the answer to some important questions has to be found before.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 05:01:04