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Titolo:
CIRCULATING IMMUNOGLOBULIN-SECRETING CELLS ARE HETEROGENEOUS IN THEIREXPRESSION OF MATURATION MARKERS AND HOMING RECEPTORS
Autore:
KANTELE JM; KANTELE A; ARVILOMMI H;
Indirizzi:
NATL INST PUBL HLTH,POB 57 SF-20521 TURKU FINLAND NATL INST PUBL HLTH SF-20521 TURKU FINLAND NATL INST PUBL HLTH HELSINKI FINLAND
Titolo Testata:
Clinical and experimental immunology
fascicolo: 3, volume: 104, anno: 1996,
pagine: 525 - 530
SICI:
0009-9104(1996)104:3<525:CICAHI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN IMMUNE-RESPONSE; HUMAN-PLASMA CELLS; SALMONELLA-TYPHI; PERIPHERAL-BLOOD; LYMPH-NODE; INTESTINAL LYMPHOCYTES; MONOCLONAL-ANTIBODY; ADHESION MOLECULE; HIGH ENDOTHELIUM; IGA PRODUCTION;
Keywords:
IMMUNOGLOBULIN-SECRETING CELLS; IMMUNOMAGNETIC CELL SORTING; ELISPOT; HOMING RECEPTORS; LYMPHOCYTE HOMING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Kantele et al., "CIRCULATING IMMUNOGLOBULIN-SECRETING CELLS ARE HETEROGENEOUS IN THEIREXPRESSION OF MATURATION MARKERS AND HOMING RECEPTORS", Clinical and experimental immunology, 104(3), 1996, pp. 525-530

Abstract

Immunoglobulin-secreting cells (ISC) in the peripheral blood are active effecters of the human immune defence system on their way to their site of action. We combined immunomagnetic cell separation and ELISPOTto study the expression of maturation markers and homing receptors (HR) on these cells in healthy volunteers. The results revealed that although highly differentiated, peripheral blood ISC are remarkably heterogeneous both with respect to their expression of maturation markers and HR. Moreover, significant differences were demonstrated between thevarious isotypes. Fewer IgA-secreting cells expressed both markers ofearly maturation (HLA-DR, HLA-DQ, CD20, and CD21) and of more mature B cells or plasma cells (CD28, CD38, and alpha-syndecan) compared withIgG- and IgM-secreting cells. IgA-secreting cells also showed the lowest proportion of cells positive for the peripheral lymph node HR, L-selectin, or the skin HR, cutaneous lymphocyte antigen (CLA). By contrast, the expression of mucosal HR on IgA-secreting cells did not reveala more pronounced homing attitude to mucosal tissues than IgG- or IgM-secreting cells. We conclude that peripheral blood ISC are a heterogeneous cell population and that IgA-secreting cells seem to differ fromthe other isotypes both in respect of expression of HR and the various maturational markers studied.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 06:31:54