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Titolo:
JAK3 EXPRESSION IN GLOMERULAR EPITHELIA OF IGA NEPHROPATHY (IGA-N) PATIENTS
Autore:
TAKAHASHI T; SHIRASAWA T; MIYAKE K; YAHAGI Y; MATSUMURA O; ABE A; NATORI Y; YAMABE H; UTSUNOMIYA Y; MARUYAMA N; MITARAI T; SAKAI O;
Indirizzi:
TOKYO METROPOLITAN INST GERONTOL,DEPT MOLEC PATHOL,ITABASHI KU,35-2 SAKAE CHO TOKYO 173 JAPAN TOKYO METROPOLITAN INST GERONTOL,DEPT MOLEC PATHOL,ITABASHI KU TOKYO 173 JAPAN JIKEI UNIV,SCH MED,DEPT INTERNAL MED TOKYO JAPAN INT MED CTR JAPAN,RES INST,DIV PATHOPHYSIOL TOKYO JAPAN HIROSAKI UNIV,DEPT INTERNAL MED HIROSAKI AOMORI JAPAN SAITAMA MED CTR,DEPT INTERNAL MED SAITAMA JAPAN
Titolo Testata:
Clinical and experimental immunology
fascicolo: 3, volume: 104, anno: 1996,
pagine: 517 - 524
SICI:
0009-9104(1996)104:3<517:JEIGEO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD MONONUCLEAR-CELLS; GLOMERULONEPHRITIS; PATHOGENESIS;
Keywords:
JAK3; GAMMA(C) CHAIN; IGA NEPHROPATHY; GLOMERULAR EPITHELIUM; IMMUNOHISTOCHEMISTRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
T. Takahashi et al., "JAK3 EXPRESSION IN GLOMERULAR EPITHELIA OF IGA NEPHROPATHY (IGA-N) PATIENTS", Clinical and experimental immunology, 104(3), 1996, pp. 517-524

Abstract

Jak3 is a member of the Janus kinase family which plays an important role in cytokine signal transduction. Jak3 associates the gamma(c) chain of receptors for IL-2, IL-4, IL-7, IL-9 and IL-15, and is essentialfor the signal transduction of these cytokines. We have isolated Jak3kinase from renal mesangial cells and demonstrated the constitutive expression of Jak3 in glomeruli in vivo. To investigate the physiological and pathological role of Jak3 in glomeruli, we prepared anti-Jak3 antibody and analysed the localization of Jak3 in glomeruli of renal biopsy samples from various nephritis patients and normal subjects. Among 61 nephritis patients and four normal subjects investigated in the present study, Jak3 was selectively localized to glomerular epithelia of IgA-N patients (14/34 cases) and focal glomerulosclerosis patients (1/5 cases), but not detected in minimal changes (n = 6), membranous glomerulonephropathy (n = 7), crescentic glomerulonephritis (n = 4), lupus nephritis patients (n = 5), and normal subjects (n = 4). The intense immunoreactivity for Jak3 is significantly associated with the decrease in creatinine clearance (81.5 +/- 10.4 ml/min versus 104.3 +/- 29.6 ml/min; P < 0.05, Student's t-test) and the increase in level of serum creatinine (1.13 +/- 0.33 mg/dl versus 0.75 +/- 0.23 mg/dl; P < 0.01, Student's t-test) in IgA-N patients. Furthermore, gamma(c) chain was concomitantly ex pressed with Jak3 in glomerular epithelia in vivo and in vitro, suggesting that signal transduction via gamma(c)-Jak3 cascade may be involved in the pathogenesis of glomerular injury of IgA-N. Taken together with the recent findings that IL-4-secreting T lymphocytes in affected glomeruli injure glomerular epithelium, the responsiveness of glomerular epithelium for IL-4 may be pathologically enhanced in IgA-N.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 03:21:17