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Titolo:
BILIARY ATRESIA, CYTOMEGALOVIRUS, AND AGE AT REFERRAL
Autore:
TARR PI; HAAS JE; CHRISTIE DL;
Indirizzi:
CHILDRENS HOSP & MED CTR,DIV GASTROENTEROL & NUTR,4800 SAND POINT WAYNE SEATTLE WA 98105 UNIV WASHINGTON,SCH MED,DEPT PEDIAT,DIV GASTROENTEROL SEATTLE WA 98195 UNIV WASHINGTON,SCH MED,DEPT MICROBIOL SEATTLE WA 98195 CHILDRENS HOSP MICHIGAN,DEPT PATHOL DETROIT MI 48201
Titolo Testata:
Pediatrics
fascicolo: 6, volume: 97, anno: 1996,
parte:, 1
pagine: 828 - 831
SICI:
0031-4005(1996)97:6<828:BACAAA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEONATAL HEPATITIS; INFECTION; SURGERY;
Keywords:
CONJUGATED BILIRUBIN; CYTOMEGALOVIRUS; EXTRAHEPATIC BILIARY ATRESIA; PORTOENTEROSTOMY; SCREENING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
P.I. Tarr et al., "BILIARY ATRESIA, CYTOMEGALOVIRUS, AND AGE AT REFERRAL", Pediatrics, 97(6), 1996, pp. 828-831

Abstract

Objective. To determine the frequency with which patients with extrahepatic biliary atresia (EHBA) are infected with cytomegalovirus (CMV) and to ascertain the age at referral to a specialty center for surgical correction of EHBA. Methods. The charts of all patients discharged from the Children's Hospital and Medical Center between July 1, 1989 and December 31, 1993 with a new diagnosis of EHBA were reviewed to determine the frequency with which EHBA was accompanied by CMV infection. Data analyzed included age at referral and sex of patients, histopathologic evidence of CMV infection and size of bile ducts in the resectedliver, and serologic (IgM) or culture diagnosis of CMV infection. Results. Twenty-three patients with EHBA were evaluated at Children's Hospital and Medical Center in the study period. Twenty-one of the patients with EHBA were appropriately evaluated for infection with CMV and infection was documented in 5 (24%) patients. The median age of referral for all patients was 61 days (range 10 to 124 days). infected patients were referred later (82.4 +/- 28.7 days) than noninfected patients (48.8 +/- 21.8 days) (P = .01) and were more likely to be girls, but the medians of the diameters of the bile ducts in the resected porta hepatis were similar. Viral inclusions were not identified in any of theliver specimens. Conclusions. CMV infection is present in an unexpectedly large proportion of patients with EHBA at the time of referral. The establishment of CMV infection in infants with cholestasis should not deter the search for EHBA. Physicians should strive to reduce the age of referral of patients with EHBA to pediatric surgical centers by evaluating infants who remained jaundiced at 4 weeks of age.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 00:22:08