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Titolo:
CYTOTOXICITY OF SERA FROM RATS WITH PUROMYCIN AMINONUCLEOSIDE NEPHROSIS
Autore:
NATORI Y; IGAWA Y; NAKAO N; NATORI Y;
Indirizzi:
INT MED CTR JAPAN,RES INST,DIV PATHOPHYSIOL,SHINJUKU KU,1-21-1 TOYAMATOKYO 162 JAPAN
Titolo Testata:
Nephron
fascicolo: 2, volume: 73, anno: 1996,
pagine: 258 - 263
SICI:
0028-2766(1996)73:2<258:COSFRW>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; GLOMERULAR EPITHELIAL-CELLS; LATE RENAL INJURY; CYTO-TOXICITY; INVITRO; GLOMERULOSCLEROSIS; CHOLESTEROL; PROTEINURIA; OXIDATION; SCLEROSIS;
Keywords:
NEPHROTIC SYNDROME; HYPERLIPIDEMIA; ENDOTHELIAL CELLS; GLOMERULAR INJURY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
Y. Natori et al., "CYTOTOXICITY OF SERA FROM RATS WITH PUROMYCIN AMINONUCLEOSIDE NEPHROSIS", Nephron, 73(2), 1996, pp. 258-263

Abstract

Administration of puromycin aminonucleoside (PAN) to rats induces acute nephrosis with hyperlipidemia, and, in some experimental conditions, it results in chronic focal glomerulosclerosis, In this study, we examined the cytotoxicity of serum ii om rats with PAN-induced nephrosis, since hypercholesterolemia is considered to cause injury to vascularwalls in atherosclerosis, the mechanism of which is analogous to thatof glomerulosclerosis. About half of the tested sera from nephrotic rats (9 out of 17) were cytotoxic to cultured aortic endothelial cells,The toxic substance(s) was heat-stable and was extracted in the lipidFraction. Serum levels of triglyceride and cholesterol were markedly higher in the group of rats with cytotoxic serum than in the group with noncytotoxic serum, No cytotoxicity was associated with sera from control rats or the corresponding lipid fractions, Cytotoxic sera were also effective against cultured glomerular epithelial and mesangial cells, These results indicate that cytotoxic lipid is produced in rats with PAN nephrosis and the results raise tile possibility that the cytotoxic lipid in nephrotic serum might contribute to lipid-mediated glomerular injury which may induce glomerulosclerosis at a subsequent stage.

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Documento generato il 19/09/20 alle ore 07:25:53