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Titolo:
DISCOVERY AND OPTIMIZATION OF A NOVEL CLASS OF ORALLY-ACTIVE NONPEPTIDIC ENDOTHELIN-A RECEPTOR ANTAGONISTS
Autore:
RIECHERS H; ALBRECHT HP; AMBERG W; BAUMANN E; BERNARD H; BOHM HJ; KLINGE D; KLING A; MULLER S; RASCHACK M; UNGER L; WALKER N; WERNET W;
Indirizzi:
BASF AG,HAUPTLAB D-67056 LUDWIGSHAFEN GERMANY KNOLL AG D-67008 LUDWIGSHAFEN GERMANY
Titolo Testata:
Journal of medicinal chemistry
fascicolo: 11, volume: 39, anno: 1996,
pagine: 2123 - 2128
SICI:
0022-2623(1996)39:11<2123:DAOOAN>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPRESSION; CLONING; CDNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
H. Riechers et al., "DISCOVERY AND OPTIMIZATION OF A NOVEL CLASS OF ORALLY-ACTIVE NONPEPTIDIC ENDOTHELIN-A RECEPTOR ANTAGONISTS", Journal of medicinal chemistry, 39(11), 1996, pp. 2123-2128

Abstract

A novel class of endothelin-A receptor ligands was discovered by high-throughput screening. Lead structure optimization led to highly potent antagonists which can be synthesized in a short sequence. The compounds are endothelin-A-selective, are orally available, and show a long duration of action.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 11:56:26