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Titolo:
HERITABILITY OF INHIBITORY GATING OF THE P50 AUDITORY-EVOKED POTENTIAL IN MONOZYGOTIC AND DIZYGOTIC TWINS
Autore:
YOUNG DA; WALDO M; RUTLEDGE JH; FREEDMAN R;
Indirizzi:
UNIV COLORADO,SCH MED,DEPT PSYCHIAT,CAMPUS BOX C268-71,4200 E 9TH AVEDENVER CO 80262 UNIV COLORADO,SCH MED,DEPT PSYCHIAT DENVER CO 80262 UNIV COLORADO,SCH MED,DEPT PREVENT MED & BIOMETR DENVER CO 80262 VET ADM MED CTR DENVER CO 80220
Titolo Testata:
Neuropsychobiology
fascicolo: 3, volume: 33, anno: 1996,
pagine: 113 - 117
SICI:
0302-282X(1996)33:3<113:HOIGOT>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHIZOPHRENIA; SUPPRESSION; SIMILARITY;
Keywords:
HERITABILITY; AUDITORY-EVOKED POTENTIAL; TWINS, MONOZYGOTIC AND DIZYGOTIC; LIKELIHOOD PROFILE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
D.A. Young et al., "HERITABILITY OF INHIBITORY GATING OF THE P50 AUDITORY-EVOKED POTENTIAL IN MONOZYGOTIC AND DIZYGOTIC TWINS", Neuropsychobiology, 33(3), 1996, pp. 113-117

Abstract

Most normal subjects suppress the P50 evoked response to repeated auditory stimulus when paired stimuli are presented, 500 ms apart. The ratio of the amplitude of the response to the second stimulus to that ofthe first forms a quantitative measure of the activity of a central inhibitory sensory gating mechanism. The variance of this measure in a group of monozygotic and dizygotic twin pairs was determined. The calculation of heritability (h(2)) indicates that a significant portion ofthe variance (0.44 or greater) is due to heritable factors. This study supports the use of the inhibitory gating of the P50 response as a phenotype for genetic studies of schizophrenia in which a P50 gating abnormality has been identified.

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Documento generato il 23/01/20 alle ore 03:44:37