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Titolo:
AGE-ASSOCIATED DECREMENTS IN DOPAMINE D-2 RECEPTORS IN THALAMUS AND IN TEMPORAL INSULA OF HUMAN-SUBJECTS
Autore:
WANG GJ; VOLKOW ND; FOWLER JS; LOGAN J; GUR R; NETUSIL N; HITZEMANN RJ; PAPPAS NS;
Indirizzi:
BROOKHAVEN NATL LAB,DEPT MED UPTON NY 11973 BROOKHAVEN NATL LAB,DEPT CHEM UPTON NY 11973 SUNY STONY BROOK,DEPT RADIOL STONY BROOK NY 11794 SUNY STONY BROOK,DEPT PSYCHIAT STONY BROOK NY 11794 UNIV PENN,DEPT PSYCHIAT PHILADELPHIA PA 19119
Titolo Testata:
Life sciences
fascicolo: 1, volume: 59, anno: 1996,
pagine: 31 - 35
SICI:
0024-3205(1996)59:1<31:ADIDDR>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-BRAIN; POSITRON TOMOGRAPHY; C-11 RACLOPRIDE; BINDING-SITES; PET;
Keywords:
AGING; EXTRASTRIATAL DOPAMINE RECEPTORS; [C-11] RACLOPRIDE; POSITRON EMISSION TOMOGRAPHY;
Tipo documento:
Letter
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
G.J. Wang et al., "AGE-ASSOCIATED DECREMENTS IN DOPAMINE D-2 RECEPTORS IN THALAMUS AND IN TEMPORAL INSULA OF HUMAN-SUBJECTS", Life sciences, 59(1), 1996, pp. 31-35

Abstract

This study evaluates the effects of age on DA D-2 receptors in extrastriatal regions. DA D-2 receptor availability was evaluated in 42 healthy male subjects (mean age 41 +/- 16, range 21 - 86 year old) with positron emission tomography (PET) and [C-11]raclopride. Estimates of B-max/K-d were obtained using the ratio of the distribution volume in the region of interest (caudate, putamen, thalamus, frontal, occipital cortices, temporal insula, cingulate and orbitofrontal gyri) to that incerebellum. Correlations between age and D-2 receptors were significant in putamen (r = -0.58, p less than or equal to 0.0001), caudate (r = -0.54, p less than or equal to 0.0002), thalamus (r = -0.33, p less than or equal to 0.03) and temporal insula (r = -0.39, p less than or equal to 0.01) but not in any of the frontal regions. The decrease in DA D-2 receptor availability was 6.6% per decade in caudate, 8.2% in putamen, 7.6% in thalamus and 13% in temporal insula. This study indicates that D2 losses with age are not limited to striatum and involve also thalamic as well as temporal cortical regions.

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Documento generato il 25/01/20 alle ore 18:39:08