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Titolo:
ROLE OF DOPAMINERGIC MECHANISMS IN THE STIMULATORY EFFECTS OF MK-801 INJECTED INTO THE VENTRAL TEGMENTAL AREA AND THE NUCLEUS-ACCUMBENS
Autore:
NARAYANAN S; WILLINS D; DALIA A; WALLACE L; URETSKY N;
Indirizzi:
OHIO STATE UNIV,COLL PHARM,DIV PHARMACOL,500 W 12TH AVE COLUMBUS OH 43210 OHIO STATE UNIV,COLL PHARM,DIV PHARMACOL COLUMBUS OH 43210
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 3, volume: 54, anno: 1996,
pagine: 565 - 573
SICI:
0091-3057(1996)54:3<565:RODMIT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR ANTAGONIST MK-801; INDUCED LOCOMOTOR-ACTIVITY; NMDA RECEPTOR; HYPERMOTILITY RESPONSE; DIZOCILPINE MK-801; FIRING PATTERN; NEURONS; RAT; PHENCYCLIDINE; AGONISTS;
Keywords:
MK-801; VENTRAL TEGMENTAL AREA; NUCLEUS ACCUMBENS; DOPAMINE; BACLOFEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
S. Narayanan et al., "ROLE OF DOPAMINERGIC MECHANISMS IN THE STIMULATORY EFFECTS OF MK-801 INJECTED INTO THE VENTRAL TEGMENTAL AREA AND THE NUCLEUS-ACCUMBENS", Pharmacology, biochemistry and behavior, 54(3), 1996, pp. 565-573

Abstract

The bilateral administration of 10 mu g of (+)MK-801, but not (-)MK-801, into either the VTA or the N.Ac. stimulated locomotor activity. The stimulation induced by (+)MK-801 at both sites was inhibited by reserpine (5 mg/kg, SC) and the D-1 antagonist, SCH 23390 (0.1 mg/kg, SC). Eticlopride (0.03 mg/kg, SC), a D-2 antagonist, inhibited the stimulation produced by MK-801 in the VTA but not in the N.Ac. Baclofen (32 ng), a GABA(B) receptor agonist, injected into the VTA inhibited the stimulatory response to MK-801 injected systemically, into the VTA, or into the N.Ac., but did not significantly inhibit spontaneous locomotion or the stimulatory response to apomorphine (5 mg/kg, SC). These observations suggest that the stimulatory effects of MK-801 in the VTA andthe N.Ac. are dependent on endogenous dopamine. In addition, the effects produced by MK-801 injected into the VTA closely resemble those produced by the systemic administration of low doses of MK-801, suggesting that this is the primary site of action of MK-801.

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Documento generato il 23/01/20 alle ore 03:34:24