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Titolo:
ROLE OF CATECHOLAMINES IN PLATELET-FUNCTION - PATHOPHYSIOLOGICAL AND CLINICAL-SIGNIFICANCE
Autore:
ANFOSSI G; TROVATI M;
Indirizzi:
UNIV TURIN,DEPT CLIN & BIOL SCI,DIABET UNIT,OSPED S LUIGI GONZAGA I-10043 ORBASSANO TO ITALY
Titolo Testata:
European journal of clinical investigation
fascicolo: 5, volume: 26, anno: 1996,
pagine: 353 - 370
SICI:
0014-2972(1996)26:5<353:ROCIP->2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-ADRENERGIC RECEPTORS; HUMAN-BLOOD PLATELETS; CANINE CORONARY-ARTERIES; INSULIN-INDUCED HYPOGLYCEMIA; ADENYLATE-CYCLASE ACTIVITY; ASPIRIN-TREATED PLATELETS; VASCULAR SMOOTH-MUSCLE; INTACT HUMAN-PLATELETS; CYCLIC FLOW VARIATIONS; PROTEIN-KINASE-C;
Keywords:
ADRENALINE; ADRENOCEPTORS; CATECHOLAMINES; DOPAMINE; NORADRENALINE; PLATELET ACTIVATION; PLATELETS; SYMPATHOADRENOMEDULLARY SYSTEM;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
360
Recensione:
Indirizzi per estratti:
Citazione:
G. Anfossi e M. Trovati, "ROLE OF CATECHOLAMINES IN PLATELET-FUNCTION - PATHOPHYSIOLOGICAL AND CLINICAL-SIGNIFICANCE", European journal of clinical investigation, 26(5), 1996, pp. 353-370

Abstract

Platelets are involved in the pathogenesis of vascular damage in bothatherosclerosis and arterial hypertension. Their reactivity in vivo is influenced by different factors, including sympathoadrenal activation, plasma levels of atherogenic lipoproteins and haemorrheological changes. In the present review, we examine the modulation of platelet function by the sympathoadrenal system and concentrate on the role of circulating catecholamines in the control of platelet responses. Human platelets exhibit both adrenergic and dopaminergic receptors that are influenced by different catecholamines. alpha(2)-Adrenoceptors of alpha(2A) subtype prevail on platelet membrane; through their stimulation, catecholamines potentiate the effects of other agonists and, at higher concentrations, initiate platelet responses, including aggregation, secretion and arachidonate pathway activation. Physiological and pathological conditions causing sympathoadrenal activation in vivo, i.e. physical activity, mental stress, insulin-induced hypoglycaemia, acute coronary ischaemia and heart failure, modify the circulating platelet populations and modulate platelet reactivity through an increase in circulating catecholamines. A sympathoadrenal hyperactivation modifies the function of circulating platelets through direct catecholamine effects, catecholamine-induced changes of haemodynamic factors and lipid pattern and inhibition of the vascular eicosanoid synthesis. The catecholamine effects on platelet function can be involved in the interplay among stress, adrenomedullary system activation and cardiovascular diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 05:52:17