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Titolo:
PRIMARY BILIARY-CIRRHOSIS - IMMUNOPATHOGENESIS AND OPTIMUM MANAGEMENT
Autore:
LILLY L; BERG CL; GOLLAN JL;
Indirizzi:
HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DIV GASTROENTEROL,75 FRANCIS ST BOSTON MA 02115 HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DIV GASTROENTEROL BOSTON MA 02115 HARVARD UNIV,CTR DIGEST DIS BOSTON MA 02115
Titolo Testata:
CLINICAL IMMUNOTHERAPEUTICS
fascicolo: 6, volume: 5, anno: 1996,
pagine: 420 - 437
SICI:
1172-7039(1996)5:6<420:PB-IAO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
URSODEOXYCHOLIC ACID THERAPY; CHRONIC LIVER-DISEASE; PRIMARY SCLEROSING CHOLANGITIS; CHRONIC ACTIVE HEPATITIS; LAMIN-B-RECEPTOR; HLA-DR ANTIGENS; CIRCULATING IMMUNE-COMPLEXES; BLOOD MONONUCLEAR-CELLS; CONTROLLED TRIAL; BILE-ACIDS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
190
Recensione:
Indirizzi per estratti:
Citazione:
L. Lilly et al., "PRIMARY BILIARY-CIRRHOSIS - IMMUNOPATHOGENESIS AND OPTIMUM MANAGEMENT", CLINICAL IMMUNOTHERAPEUTICS, 5(6), 1996, pp. 420-437

Abstract

Primary biliary cirrhosis is a well-characterised disorder of autoimmune origin whose exact pathogenesis remains poorly understood. Population studies have suggested an association with human leucocyte antigen(HLA)-DR8, and patients are universally positive for antimitochondrial antibodies; however, the clinical relevance of these observations isunclear, Other putative autoantigens have been proposed, Numerous abnormalities throughout the immune system as well as in complement pathways have been characterised, and major histocompatibility complex (MHC) expression on biliary epithelial cells is increased, Consequently, drugs whose actions are primarily immunomodulatory have undergone testing in the therapy of primary biliary cirrhosis, but none have demonstrated particular promise. Ursodeoxycholic acid remains the therapy of choice, and it is believed to exert its beneficial effects by modifyingbile salt pool content and kinetics, as well as possibly through immunological mechanisms, Improvement in biochemical and clinical parameters with ursodeoxycholic acid therapy is well recognised, and it also appears to improve hepatic histology and retard progression Co transplantation or death, Antifibrotic therapy with colchicine has shown some promise in small studies; however, the results of larger clinical trials designed to examine its role in conjunction with ursodeoxycholic acid are not yet available, Liver transplantation is the established treatment for end-stage primary biliary cirrhosis, and recurrent disease in the allograft has not been satisfactorily documented.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:13:39