Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INCREASED INSULIN-RESISTANCE AND INSULIN-SECRETION IN NONDIABETIC AFRICAN-AMERICANS AND HISPANICS COMPARED WITH NON-HISPANIC WHITES - THE INSULIN-RESISTANCE ATHEROSCLEROSIS STUDY
Autore:
HAFFNER SM; DAGOSTINO R; SAAD MF; REWERS M; MYKKANEN L; SELBY J; HOWARD G; SAVAGE PJ; HAMMAN RF; WAGENKNECHT LE; BERGMAN RN;
Indirizzi:
UNIV TEXAS,HLTH SCI CTR,DEPT MED,7703 FLOYD CURL DR SAN ANTONIO TX 78284 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT PUBL HLTH SCI WINSTON SALEMNC 27103 UNIV SO CALIF,SCH MED,DEPT MED LOS ANGELES CA 90033 UNIV SO CALIF,SCH MED,DEPT PHYSIOL & BIOPHYS LOS ANGELES CA 90033 UNIV COLORADO,SCH MED,DEPT PREVENT MED BIOMETR DENVER CO 00000 UNIV KUOPIO,DEPT MED SF-70210 KUOPIO FINLAND KAISER PERMANENTE,DIV RES OAKLAND CA 00000 NHLBI,NIH,DIV EPIDEMIOL & CLIN APPLICAT BETHESDA MD 20892
Titolo Testata:
Diabetes
fascicolo: 6, volume: 45, anno: 1996,
pagine: 742 - 748
SICI:
0012-1797(1996)45:6<742:IIAIIN>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; IMPAIRED GLUCOSE-TOLERANCE; MEXICAN-AMERICANS; PIMA-INDIANS; RISK-FACTORS; C-PEPTIDE; CARDIOVASCULAR RISK; FAT DISTRIBUTION; FASTING INSULIN; MINIMAL MODEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
S.M. Haffner et al., "INCREASED INSULIN-RESISTANCE AND INSULIN-SECRETION IN NONDIABETIC AFRICAN-AMERICANS AND HISPANICS COMPARED WITH NON-HISPANIC WHITES - THE INSULIN-RESISTANCE ATHEROSCLEROSIS STUDY", Diabetes, 45(6), 1996, pp. 742-748

Abstract

The etiology of NIDDM is still controversial, with both insulin resistance and decreased insulin secretion postulated as potential important factors, African-Americans and Hispanics have a two- to threefold excess risk of developing NIDDM compared with non-Hispanic whites, Yet little is known concerning the prevalence of insulin resistance and secretion defects in minorities, especially in African-Americans in population-based studies, Fasting and 2-h post-glucose load glucose and insulin levels, insulin-mediated glucose disposal (insulin sensitivity index) (S-I), glucose effectiveness (S-G), and first-phase insulin response (acute insulin response [AIR]) were determined in nondiabetic African-Americans (n = 288), Hispanics (n = 363), and non-Hispanic whites (n = 435) as part of the Insulin Resistance Atherosclerosis Study, Subjects received a standard 2-h oral glucose tolerance test on the firstday and an insulin-modified frequently sampled intravenous glucose tolerance test on the second day, African-Americans and Hispanics were more obese than non-Hispanic whites, Both African-Americans and Hispanics had higher fasting and 2-h insulin concentrations and AIR but lowerS-I than non-Hispanic whites, No ethnic difference was observed in S-G. After further adjustments for obesity, body fat distribution, and behavioral factors, African-Americans continued to have higher fasting and 2-h insulin levels and AIR, but lower S-I, than non-Hispanic whites, In contrast, after adjustment for these covariates, no significant ethnic differences in S-I or fasting insulin levels were observed between Hispanics and non-Hispanic whites, Hispanics continued to have higher 2-h insulin levels and AIRs than those in non-Hispanic whites, In this report, the association between S-I and upper body adiposity (waist-to-hip ratio) was similar in each ethnic group, Both nondiabetic African-Americans and Hispanics have increased insulin resistance and higher AIR than nondiabetic non-Hispanic whites, suggesting that greaterinsulin resistance may be in large part responsible for the higher prevalence of NIDDM in these minority groups, However, in Hispanics, thegreater insulin resistance may be due to greater adiposity and other behavioral factors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:37:28