Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
RHYTHMICAL ORAL-MOTOR ACTIVITY RECORDED IN AN IN-VITRO BRAIN-STEM PREPARATION
Autore:
KOGO M; FUNK GD; CHANDLER SH;
Indirizzi:
UNIV CALIF LOS ANGELES,DEPT PHYSIOL SCI,2851 SLICHTER HALL LOS ANGELES CA 90095 UNIV CALIF LOS ANGELES,DEPT PHYSIOL SCI LOS ANGELES CA 90095
Titolo Testata:
Somatosensory & motor research
fascicolo: 1, volume: 13, anno: 1996,
pagine: 39 - 48
SICI:
0899-0220(1996)13:1<39:ROARIA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPINAL-CORD PREPARATIONS; GUINEA-PIG; FICTIVE LOCOMOTION; RESPIRATORY RHYTHM; JAW MOVEMENTS; RETICULAR NEURONS; NEONATAL RAT; INVITRO; MASTICATION; GENERATION;
Keywords:
MASTICATION; SUCKLING; EXCITATORY AMINO ACIDS; TRIGEMINAL NERVE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
M. Kogo et al., "RHYTHMICAL ORAL-MOTOR ACTIVITY RECORDED IN AN IN-VITRO BRAIN-STEM PREPARATION", Somatosensory & motor research, 13(1), 1996, pp. 39-48

Abstract

The present study employed the neonatal rat isolated brainstem preparation to determine whether oral-motor rhythmical activity, a substratefor the complex behaviors of suckling and chewing, could be elicited in vitro by bath application of excitatory amino acids (EAAs). Bath application of EAA agonists (kainate [KA], -]-a-amino-3-hydroxy-5-methylisoxazole-4-propionic acid [AMPA], N-methyl-D L-aspartate [NMA]), in conjunction with the gamma-aminobutyric acid antagonist bicuculline, either failed to induce rhythmic activity (n = 17 preparations) or induced a low-amplitude, low-frequency burst discharge (<1 Hz, n = 10 preparations) from the motor branches of the trigeminal nerves when the brainstem was contiguous from the spinomedullary junction to the superiorcolliculus. Burst activity was in most cases bilaterally synchronous. However, when a discrete coronal transection was made at the level ofthe facial colliculus, between the trigeminal and facial motor nuclei, the rhythmic bursts produced by the resultant 3- to 5-mm block of tissue following bath application of EAA agonists increased in amplitudeand frequency (4-8 Hz, n = 35). Application of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), a non-N-methyl-D-aspartate (non-NMDA) receptor antagonist, blocked the rhythm induced by non-NMDA receptor agonist (n= 4) but was less effective in suppressing NMA-induced rhythmicity. In contrast, D,L-2-amino-5-phosphonovaleric acid (APV) blocked both NMA-induced (n = 5) and, in most cases, KA-induced(n = 5) rhythmicity, suggesting an essential role for NMA receptors in production of EAA-induced rhythmical oral-motor activity in the neonatal rat. The present data demonstrate that a narrow, bilaterally distributed region of brainstem surrounding the trigeminal motor nucleus contains sufficient neuronal circuitry for the production of oral-motor rhythmogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 02:04:06