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Titolo:
NITRIC-OXIDE COMPLEMENTS PROSTACYCLIN IN THE REGULATION OF ENDOTHELIAL THROMBORESISTANCE UNDER FLOW CONDITIONS
Autore:
KORBUT R; OCETKIEWICZ A; GRYGLEWSKI RJ;
Indirizzi:
NICOLAUS COPERNICUS UNIV,SCH MED,DEPT PHARMACOL,GRZEGORZECKA 16 PL-31531 KRAKOW POLAND
Titolo Testata:
Methods and findings in experimental and clinical pharmacology
fascicolo: 3, volume: 15, anno: 1993,
pagine: 179 - 181
SICI:
0379-0355(1993)15:3<179:NCPITR>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR SMOOTH-MUSCLE; L-ARGININE; LEUKOCYTES; PLATELETS; ILOPROST;
Keywords:
THROMBORESISTANCE; THROMBOGENICITY; ENDOTHELIUM; NITRIC OXIDE; PROSTACYCLIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
R. Korbut et al., "NITRIC-OXIDE COMPLEMENTS PROSTACYCLIN IN THE REGULATION OF ENDOTHELIAL THROMBORESISTANCE UNDER FLOW CONDITIONS", Methods and findings in experimental and clinical pharmacology, 15(3), 1993, pp. 179-181

Abstract

Using a novel method of measuring thrombogenesis on the surface of rabbit aorta endothelium superfused with whole blood, it was demonstrated that the thrombogenic properties of endothelium are potentiated by pretreatment with inhibitors of nitric oxide (NO) synthase (NG-monomethyl-L-arginine, MeArg, 100 mcM) or cyclooxygenase (aspirin, ASA, 60 mcM). Since MeArg is less effective than aspirin and moreover does not influence thrombogenesis after previous inhibition of the synthesis of PGI2, it is concluded that the generation of NO by vascular endotheliumcomplements PGI2 in its antithrombotic activity but NO may be ineffective when the generation of PGI2 has been impaired.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 09:12:20