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Titolo: EFFECT OF CHRONIC EXPERIMENTAL DIABETES ON VASCULAR SMOOTH-MUSCLE FUNCTION IN DOG FEMORAL-ARTERY
Autore: SARIOGLU Y; UTKAN T; UTKAN NZ; BOZKURT A;
- Indirizzi:
- CUMHURIYET UNIV,FAC MED,DEPT PHARMACOL SIVAS TURKEY HACETTEPE UNIV,FAC MED,DEPT PHARMACOL ANKARA TURKEY CUMHURIYET UNIV,FAC MED,DEPT GEN SURG SIVAS TURKEY
- Titolo Testata:
- Methods and findings in experimental and clinical pharmacology
fascicolo: 3,
volume: 15,
anno: 1993,
pagine: 161 - 167
- SICI:
- 0379-0355(1993)15:3<161:EOCEDO>2.0.ZU;2-U
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- ENDOTHELIUM; RESPONSES; DISEASE; RABBIT; CELL;
- Keywords:
- REACTIVITY OF ARTERIES; DIABETES; ENDOTHELIUM; ACETYLCHOLINE; SEROTONIN; NORADRENALINE;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Science Citation Index Expanded
- Citazioni:
- 24
- Recensione:
- Indirizzi per estratti:
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- Citazione:
- Y. Sarioglu et al., "EFFECT OF CHRONIC EXPERIMENTAL DIABETES ON VASCULAR SMOOTH-MUSCLE FUNCTION IN DOG FEMORAL-ARTERY", Methods and findings in experimental and clinical pharmacology, 15(3), 1993, pp. 161-167
Abstract
To understand the effects of diabetes on vascular smooth muscle function and the underlying mechanisms involved, we examined the responses to noradrenaline (NA), serotonin, KCl and acetylcholine in the femoralartery of mongrel dogs with chronic diabetes (3 months)-induced subtotal pancreatectomy. Isolated ring segments of diabetic dog femoral artery exhibited an increased response to serotonin, a decreased responseto NA, an unchanged response to KCl and a decreased endothelium-dependent relaxation to acetylcholine as compared with controls. The sensitivity (pD2) of diabetic femoral artery rings to NA and serotonin was markedly diminished. These results suggest that changed responsiveness of arteries from diabetic animals to NA, serotonin and acetylcholine could be the reflection of an alteration in the contractile machinery or the result of a decrease in endothelium-derived relaxing factor release in diabetic blood vessels.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:31:03