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Titolo:
EFFECT OF POLICOSANOL ON FOAM-CELL FORMATION IN CARRAGEENAN-INDUCED GRANULOMAS IN RATS
Autore:
NOA M; DELAROSA MC; MAS R;
Indirizzi:
NATL CTR SCI RES,HISTOL LAB,POB 6990 HAVANA 6880 CUBA
Titolo Testata:
Journal of Pharmacy and Pharmacology
fascicolo: 3, volume: 48, anno: 1996,
pagine: 306 - 309
SICI:
0022-3573(1996)48:3<306:EOPOFF>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVOLUTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
M. Noa et al., "EFFECT OF POLICOSANOL ON FOAM-CELL FORMATION IN CARRAGEENAN-INDUCED GRANULOMAS IN RATS", Journal of Pharmacy and Pharmacology, 48(3), 1996, pp. 306-309

Abstract

Policosanol is a new cholesterol-lowering drug isolated and purified From sugar-cane wax, which prevents the development of lipofundin-induced lesions and foam-cell formation in New Zealand rabbits and Wistar rats. This study was conducted to examine the effects of policosanol on foam-cell formation in carrageenan-induced granulomas in rats. Eighteen Wistar rats were randomly distributed in three experimental groupswhich received orally for 20 days Tween 20 H2O as vehicle (control group) or policosanol at 2.5 or 25 mg kg(-1). At the 11th day, lipofundin was injected intraperitoneally for 8 days to induce formation of foam cells in the granuloma. At day 13, carrageenan was injected subcutaneously for granuloma induction and seven days later animals were killed. A significant reduction of the foam-cell formation in granulomas ofpolicosanol-treated rats was observed. It is concluded that policosanol prevents the development of foam cells in carrageenan-induced granulomas (extravascular medium) in rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 09:19:30