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Titolo:
THYMOPENTIN IN SOLID LIPID NANOPARTICLES
Autore:
MOREL S; UGAZIO E; CAVALLI R; GASCO MR;
Indirizzi:
DIPARTIMENTO SCI & TECNOL FARM,VIA P GIURIA 9 I-10125 TURIN ITALY DIPARTIMENTO SCI & TECNOL FARM I-10125 TURIN ITALY
Titolo Testata:
International journal of pharmaceutics
fascicolo: 1-2, volume: 132, anno: 1996,
pagine: 259 - 261
SICI:
0378-5173(1996)132:1-2<259:TISLN>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIPOSPHERES;
Keywords:
THYMOPENTIN; WARM O/W AND W/O/W MICROEMULSIONS; SOLID LIPID NANOPARTICLES; POLYPEPTIDES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
S. Morel et al., "THYMOPENTIN IN SOLID LIPID NANOPARTICLES", International journal of pharmaceutics, 132(1-2), 1996, pp. 259-261

Abstract

The pentapeptide thymopentin was englobed in solid lipid nanoparticles prepared from warm microemulsions following two different methods: from O/W microemulsion by forming the more lipophilic ion-pair with hexadecylphosphate, and from W/O/W microemulsion by dissolving the pentapeptide in the aqueous internal phase. The incorporation of the hydrophilic drug was 5.2% and 1.7% respectively; in both cases, the in vitro release of thymopentin from the solid lipid nanoparticles followed a pseudo-zero-order kinetics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 03:37:06