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Titolo:
POLYGENIC INHERITANCE OF TOURETTE SYNDROME, STUTTERING, ATTENTION-DEFICIT HYPERACTIVITY, CONDUCT, AND OPPOSITIONAL DEFIANT DISORDER - THE ADDITIVE AND SUBTRACTIVE EFFECT OF THE 3 DOPAMINERGIC GENES - DRD2, D-BETA-H, AND DAT1
Autore:
COMINGS DE; WU S; CHIU C; RING RH; GADE R; AHN C; MACMURRAY JP; DIETZ G; MUHLEMAN D;
Indirizzi:
CITY HOPE NATL MED CTR,DEPT MED GENET,1500 E DUARTE RD DUARTE CA 91010 JERRY L PETTIS MEM VET ADM MED CTR LOMA LINDA CA 00000
Titolo Testata:
American journal of medical genetics
fascicolo: 3, volume: 67, anno: 1996,
pagine: 264 - 288
SICI:
0148-7299(1996)67:3<264:PIOTSS>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSESSIVE-COMPULSIVE DISORDER; EMOTIONALLY-DISTURBED BOYS; D2-DOPAMINE RECEPTOR GENE; ALLELIC ASSOCIATION; PSYCHIATRIC-PATIENTS; HYDROXYLASE ACTIVITY; ALCOHOLISM; LINKAGE; LOCUS; TRANSPORTER;
Keywords:
POLYGENIC; ATTENTION DEFICIT; HYPERACTIVITY DISORDER; ADHD; CONDUCT DISORDER; TOURETTE SYNDROME; DOPAMINE; DRD2; D-BETA-H; DAT1; TRANSPORTER;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
143
Recensione:
Indirizzi per estratti:
Citazione:
D.E. Comings et al., "POLYGENIC INHERITANCE OF TOURETTE SYNDROME, STUTTERING, ATTENTION-DEFICIT HYPERACTIVITY, CONDUCT, AND OPPOSITIONAL DEFIANT DISORDER - THE ADDITIVE AND SUBTRACTIVE EFFECT OF THE 3 DOPAMINERGIC GENES - DRD2, D-BETA-H, AND DAT1", American journal of medical genetics, 67(3), 1996, pp. 264-288

Abstract

Polymorphisms of three different dopaminergic genes, dopamine D-2 receptor (DRD2), dopamine beta-hydroxylase (D beta H), and dopamine transporter (DAT1), were examined in Tourette syndrome (TS) probands, theirrelatives, and controls. Each gene individually showed a significant correlation with various behavioral variables in these subjects. The additive and subtractive effects of the three genes were examined by genotyping all three genes in the same set of subjects. For 9 of 20 TS associated comorbid behaviors there was a significant linear association between the degree of loading for markers of three genes and the mean behavior scores. The behavior variables showing the significant associations were, in order, attention deficit hyperactivity disorder (ADHD), stuttering, oppositional defiant, ties, conduct, obsessive-compulsive, mania, alcohol abuse, and general anxiety - behaviors that constitute the most overt clinical aspects of TS. For 16 of the 20 behavior scores there was a linear progressive decrease in the mean score with progressively lesser loading for the three gene markers. These resultssuggest that TS, ADHD, stuttering, oppositional defiant and conduct disorder, and other behaviors associated with TS, are polygenic, due inpart to these three dopaminergic genes, and that the genetics of other polygenic psychiatric disorders may be deciphered using this technique. (C) 1996 Wiley-Liss, Inc.

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Documento generato il 04/12/20 alle ore 17:36:21