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Titolo:
ANALYSIS OF BINARY-MIXTURES OF CEPHALOTHIN AND CEFOXITIN BY USING FIRST-DERIVATIVE SPECTROPHOTOMETRY
Autore:
MURILLO JA; LEMUS JM; GARCIA LF;
Indirizzi:
UNIV CASTILLA LA MANCHA,DEPT ANALYT CHEM & FOOD TECHNOL E-13071 CIUDAD REAL SPAIN
Titolo Testata:
Journal of pharmaceutical and biomedical analysis
fascicolo: 3, volume: 14, anno: 1996,
pagine: 257 - 266
SICI:
0731-7085(1996)14:3<257:AOBOCA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PURE FORM; CEPHALOSPORINS; SPECTROMETRY;
Keywords:
CEPHALOTHIN; CEFOXITIN; DERIVATIVE SPECTROPHOTOMETRY; SIMULTANEOUS DETERMINATION; PHARMACEUTICAL DOSAGE FORMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Murillo et al., "ANALYSIS OF BINARY-MIXTURES OF CEPHALOTHIN AND CEFOXITIN BY USING FIRST-DERIVATIVE SPECTROPHOTOMETRY", Journal of pharmaceutical and biomedical analysis, 14(3), 1996, pp. 257-266

Abstract

A method for the analysis of two-component mixtures of cephalothin and cefoxitin using zero-crossing first-derivative spectrophotometry is described. This technique permits the quantification of these drugs with closely overlapping spectral bands without any separation step. Linear calibration graphs of first-derivative values at 235.00 and 236.75nm for cephalothin and cefoxitin, respectively, with negligible intercepts were obtained versus concentration in the range 4.0-32.0 mu g ml(-1) for both antibiotics. This paper presents a systematic examination of the experimental data by applying an exhaustive statistical analysis to demonstrate the validity of the method. The results of the determination of these antibiotics in mixtures of injectable dosage forms are also presented, together with their determinations in physiological serum and glucosed physiological serum.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 06:33:51