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Titolo:
EFFECT OF CONDITIONED FEAR STRESS ON DOPAMINE RELEASE IN THE RAT PREFRONTAL CORTEX
Autore:
YOSHIOKA M; MATSUMOTO M; TOGASHI H; SAITO H;
Indirizzi:
HOKKAIDO UNIV,SCH MED,DEPT PHARMACOL 1,KITA KU,KITA 15,NISHI 7 SAPPORO HOKKAIDO 060 JAPAN
Titolo Testata:
Neuroscience letters
fascicolo: 3, volume: 209, anno: 1996,
pagine: 201 - 203
SICI:
0304-3940(1996)209:3<201:EOCFSO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOOTSHOCK STRESS; BRAIN; SEROTONIN; DIAZEPAM; TURNOVER; NEURONS; ACID;
Keywords:
DOPAMINE; CONDITIONED FEAR STRESS; FOOTSHOCK; FREEZING BEHAVIOR; MEDIAL PREFRONTAL CORTEX; IN VIVO MICRODIALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
M. Yoshioka et al., "EFFECT OF CONDITIONED FEAR STRESS ON DOPAMINE RELEASE IN THE RAT PREFRONTAL CORTEX", Neuroscience letters, 209(3), 1996, pp. 201-203

Abstract

The effects of conditioned fear stress (CFS) on dopamine release in the medial prefrontal cortex were studied by in vivo microdialysis in the rat. CFS (exposure to an environment in which foot-shock had been delivered previously) induced a marked suppression of motility, i.e., freezing behavior. Extracellular concentrations of dopamine in the medial prefrontal cortex were increased by CFs. The increase of dopamine returned to the pretreatment levels when rats were returned to the homecages. Diazepam (0.5 mg/kg, i.p.) suppressed both the CFS-induced freezing behavior and extracellular dopamine levels in the medial prefrontal cortex. These findings suggest that anxiety and dopamine release in the prefrontal cortex might be related.

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Documento generato il 23/09/20 alle ore 12:51:16