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Titolo:
NEW DEVELOPMENTS IN THE MOLECULAR PHARMACOLOGY OF ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLE PROPIONATE AND KAINATE RECEPTORS
Autore:
FLETCHER EJ; LODGE D;
Indirizzi:
MRC,MOLEC BIOL LAB,DEPT ZOOL CAMBRIDGE ENGLAND MRC,MOLEC BIOL LAB,DEPT ZOOL CAMBRIDGE ENGLAND LILLY RES CTR LTD WINDLESHAM GU20 6PH SURREY ENGLAND
Titolo Testata:
Pharmacology & therapeutics
fascicolo: 1, volume: 70, anno: 1996,
pagine: 65 - 89
SICI:
0163-7258(1996)70:1<65:NDITMP>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID RECEPTORS; RAT HIPPOCAMPAL-NEURONS; NMDA GLUTAMATE RECEPTOR; HIGH-AFFINITY KAINATE; BRAIN MESSENGER-RNA; SPINAL-CORD INVITRO; METHYL-D-ASPARTATE; EXCITATORY SYNAPTIC TRANSMISSION; NOOTROPIC DRUG ANIRACETAM; CENTRAL NERVOUS-SYSTEM;
Keywords:
GLUTAMATE RECEPTORS; ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLE PROPIONATE (AMPA); KAINATE; QUINOXALINEDIONE (NBQX); DECAHYDROISOQUINOLINE (LY293558); CYCLOTHIAZIDE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
246
Recensione:
Indirizzi per estratti:
Citazione:
E.J. Fletcher e D. Lodge, "NEW DEVELOPMENTS IN THE MOLECULAR PHARMACOLOGY OF ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLE PROPIONATE AND KAINATE RECEPTORS", Pharmacology & therapeutics, 70(1), 1996, pp. 65-89

Abstract

Separation of non-N-methyl-D-aspartate subtypes of glutamate receptors, known as alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) and kainate receptors, is traced through conventional pharmacology to molecular biology. The physiology and pharmacology of recombinant receptor subtypes (GluR1-7 and KA1-2) are described Competitive antagonists, e.g., the quinoxalinedione, dihydroxy-6-nitro-7-sulphamoyl-benz(F)quinoxaline, and the decahydroisoquinoline, 3S,4aR,6R,8aR-6-[2-(1(2)H-tetrazol-5-yl) ethyl]-decahydroisoquinoline-3-carboxylate, have a broad antagonist spectrum, except that the latter is inactive on GluR6. The 2,3-benzodiazepines noncompetitively antagonise the AMPA receptor GluR1-4, Desensitisation of AMPA (GluR1-4) and kainate (GluR5-7 and KA1-2) receptors is blocked by cyclothiazide and concanavalin A, respectively, Polyamine toxins block AMPA receptors not containing GluR2 and unedited kainate receptors (GluR5-6). These data correlate well with results on native neurons characterised by techniques such as in situ hybridisation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 10:15:03