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Titolo:
EXOGENOUS PULMONARY SURFACTANT AS A DRUG DELIVERING AGENT - INFLUENCEOF ANTIBIOTICS ON SURFACTANT ACTIVITY
Autore:
VANTVEEN A; GOMMERS D; MOUTON JW; KLUYTMANS JAJW; KRIJT EJ; LACHMANN B;
Indirizzi:
ERASMUS UNIV ROTTERDAM,DEPT ANAESTHESIOL ROTTERDAM NETHERLANDS ERASMUS UNIV ROTTERDAM,DEPT ANAESTHESIOL ROTTERDAM NETHERLANDS ERASMUS UNIV ROTTERDAM,DEPT CLIN MICROBIOL ROTTERDAM NETHERLANDS
Titolo Testata:
British Journal of Pharmacology
fascicolo: 3, volume: 118, anno: 1996,
pagine: 593 - 598
SICI:
0007-1188(1996)118:3<593:EPSAAD>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS SYNDROME; AMPHOTERICIN-B; CYSTIC-FIBROSIS; PRETERM LAMBS; PNEUMONIA; AEROSOL; THERAPY; REPLACEMENT; INHIBITION; SHEEP;
Keywords:
PULMONARY SURFACTANT; ANTIMICROBIAL AGENTS; ANTIBIOTICS; PNEUMONIA; SURFACTANT FUNCTION; DRUG DELIVERY; LUNG LAVAGE MODEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
A. Vantveen et al., "EXOGENOUS PULMONARY SURFACTANT AS A DRUG DELIVERING AGENT - INFLUENCEOF ANTIBIOTICS ON SURFACTANT ACTIVITY", British Journal of Pharmacology, 118(3), 1996, pp. 593-598

Abstract

1 It has been proposed to use exogenous pulmonary surfactant as a drug delivery system for antibiotics to the alveolar compartment of the lung. Little, however, is known about interactions between pulmonary surfactant and antimicrobial agents. This study investigated the activity of a bovine pulmonary surfactant after mixture with amphotericin B, amoxicillin, ceftazidime, pentamidine or tobramycin. 2 Surfactant (1 mg ml(-1) in vitro and 40 mg ml(-1) in vivo) was mixed with 0.375 mg ml(-1) amphotericin B, 50 mg ml(-1) amoxicillin, 37.5 mg ml(-1) ceftazidime, 1 mg ml(-1) pentamidine and 2.5 mg ml(-1) tobramycin. Minimal surface tension of 50 mu l of the mixtures was measured in vitro by use of the Wilhelny balance. In vivo surfactant activity was evaluated by its capacity to restore gas exchange in an established rat model for surfactant deficiency. 3 Surfactant deficiency was induced in ventilatedrats by repeated lavage of the lung with warm saline until PaO2 dropped below 80 cmH(2)O with 100% inspired oxygen at standard ventilation settings. Subsequently an antibiotic-surfactant mixture, saline, air, or surfactant alone was instilled intratracheally (4 ml kg(-1) volume,n=6 per treatment) and blood gas values were measured 5, 30, 60, 90 and 120 min after instillation. 4 The results showed that minimal surface tensions of the mixtures were comparable to that of surfactant alone. In vivo PaO2 levels in the animals receiving ceftazidime-surfactantor pentamidine-surfactant were unchanged when compared to the surfactant group. Pao(2) levels in animals receiving amphotericin B-surfactant, amoxicillin-surfactant or tobramycin-surfactant were significantly decreased compared to the surfactant group. For tobramycin it was further found that PaO2 levels were not affected when 0.2 M NaHCO3 (pH = 8.3) buffer was used for suspending surfactant instead of saline. 5 It is concluded that some antibiotics affect the in vivo activity of a bovine pulmonary surfactant. Therefore, before using surfactant-antibiotic mixtures in clinical trials, interactions between the two agents should be carefully evaluated.

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Documento generato il 05/07/20 alle ore 22:47:53