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Titolo:
7 YEAR TRENDS IN PLASMA LOW-DENSITY-LIPOPROTEIN-CHOLESTEROL IN YOUNG-ADULTS - THE CARDIA STUDY
Autore:
BILD DE; JACOBS DR; LIU K; WILLIAMS OD; HILNER JE; PERKINS LL; MARCOVINA SM; HULLEY SB;
Indirizzi:
NHLBI,DECA,2 ROCKLEDGE CTR,6701 ROCKLEDGE DR,MSC7934 BETHESDA MD 20892 UNIV MINNESOTA,DIV EPIDEMIOL MINNEAPOLIS MN 55455 NORTHWESTERN UNIV CHICAGO IL 60611 UNIV ALABAMA,CARDIA COORDINATING CTR BIRMINGHAM AL 00000 DOW CORNING CORP MIDLAND MI 00000 UNIV WASHINGTON SEATTLE WA 98195 UNIV CALIF SAN FRANCISCO SAN FRANCISCO CA 94143
Titolo Testata:
Annals of epidemiology
fascicolo: 3, volume: 6, anno: 1996,
pagine: 235 - 245
SICI:
1047-2797(1996)6:3<235:7YTIPL>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
MINNESOTA HEART SURVEY; DISEASE RISK-FACTORS; CARDIOVASCULAR-DISEASE; UNITED-STATES; SERUM-LIPIDS; MORTALITY; NUTRITION;
Keywords:
CHOLESTEROL; TRIGLYCERIDES; DIET; BODY WEIGHT; AGING; RISK FACTORS; TRENDS; COHORT STUDY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
D.E. Bild et al., "7 YEAR TRENDS IN PLASMA LOW-DENSITY-LIPOPROTEIN-CHOLESTEROL IN YOUNG-ADULTS - THE CARDIA STUDY", Annals of epidemiology, 6(3), 1996, pp. 235-245

Abstract

To identify determinants of recent secular trends in lipids and characterize their influence on age-related increases in LDL-cholesterol, we examined a cohort of black and white men and women aged 18-30 in 1985-1986. Secular trends were determined by comparing participants aged 25-30 at baseline With those aged 25-30 at year 7 (2788 and 1395 participants, respectively). LDL-cholesterol was lower among those 25-30 atyear 7 (5.9 to 10.2 mg/dL, depending on race-sex group; P < 0.001); weight was higher (8.3 to 12.5 lb; P < 0.001); Keys score was lower (-4.2 to -7.3 units; P < 0.001); and use of oral contraceptives was greater (white women only, P < 0.01). Among 4086 participants followed for 7 years, LDL-cholesterol changed little or decreased, despite substantial weight increases in all groups (11.6 to 19.0 lb; P < 0.001). Keys scores decreased by 6.1 to 8.0 units, and use of oral contraceptives decreased (P < 0.001). Declining secular trends in LDL-cholesterol occurred despite upward trends in weight; the decline was associated with lower dietary fat and cholesterol and offset expected age-related increases in LDL-cholesterol.

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Documento generato il 28/11/20 alle ore 14:34:37