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Titolo:
A DEFECTIVE V-KAPPA A2 ALLELE IN NAVAJOS WHICH PLAY PLAY A ROLE IN INCREASED SUSCEPTIBILITY TO HAEMOPHILUS-INFLUENZAE TYPE DISEASE
Autore:
FEENEY AJ; ATKINSON MJ; COWAN MJ; ESCURO G; LUGO G;
Indirizzi:
SCRIPPS CLIN & RES INST,DEPT IMMUNOL,IMM 22,10666 N TORREY PINES RD LA JOLLA CA 92037 UNIV CALIF SAN FRANCISCO,SCH MED,DEPT PEDIAT SAN FRANCISCO CA 94143
Titolo Testata:
The Journal of clinical investigation
fascicolo: 10, volume: 97, anno: 1996,
pagine: 2277 - 2282
SICI:
0021-9738(1996)97:10<2277:ADVAAI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
B CAPSULAR POLYSACCHARIDE; IGG ANTIBODY REPERTOIRE; CHAIN VARIABLE REGION; CLONAL CHARACTERIZATION; JOINING SIGNALS; USAGE; VACCINE; LOCUS; GENE; EPIDEMIOLOGY;
Keywords:
IMMUNOGLOBULIN VARIABLE REGION; GENE REARRANGEMENT; B-LYMPHOCYTES; ANTIBODY DIVERSITY; IMMUNOGLOBULIN GENES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
A.J. Feeney et al., "A DEFECTIVE V-KAPPA A2 ALLELE IN NAVAJOS WHICH PLAY PLAY A ROLE IN INCREASED SUSCEPTIBILITY TO HAEMOPHILUS-INFLUENZAE TYPE DISEASE", The Journal of clinical investigation, 97(10), 1996, pp. 2277-2282

Abstract

The antibody response to H. influenzae type b (Hib) is pauciclonal, and is dominated by antibodies using the V(k)A2 gene. Navajos have a 5-10-fold increased incidence of Hib disease compared with control populations. We hypothesized that a polymorphism in one of the genes in this oligoclonal response may lead to increased disease susceptibility. Since the predominant A2(+) anti-Hib antibodies have high avidity for Hib and can be unmutated, the A2 V-k gene was analyzed, Over half of the Navajos studied, but only one control individual, had a new allele of A2, termed A2b, with three changes from the published A2 germline sequence, One of the changes was in the recombination signal sequence, suggesting that the A2b allele might not undergo V-J rearrangement veryfrequently. This possibility was confirmed by analyzing the relative frequency of non-productive A2 rearrangements in A2a/b heterozygous Navajos. Many fewer A2b rearrangements were observed, showing that the A2b allele is defective in its ability to undergo rearrangement. The prevalence of this allele in Navajos may play a role in their increased susceptibility to invasive Hib disease. If so, it would underscore theimportance of the germline Ig repertoire for protective antibody responses to pathogenic bacteria in unimmunized children.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 19:17:09