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Titolo:
DECREASED DOPAMINE-D(2) RECEPTOR AVAILABILITY IS ASSOCIATED WITH REDUCED FRONTAL METABOLISM IN COCAINE ABUSERS
Autore:
VOLKOW ND; FOWLER JS; WANG GJ; HITZEMANN R; LOGAN J; SCHLYER DJ; DEWEY SL; WOLF AP;
Indirizzi:
BROOKHAVEN NATL LAB,DEPT MED UPTON NY 11973 BROOKHAVEN NATL LAB,DEPT CHEM UPTON NY 11973 SUNY,DEPT PSYCHIAT STONY BROOK NY 11794 VET ADM MED CTR NORTHPORT NY 11768
Titolo Testata:
Synapse
fascicolo: 2, volume: 14, anno: 1993,
pagine: 169 - 177
SICI:
0887-4476(1993)14:2<169:DDRAIA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; PROGRESSIVE SUPRANUCLEAR PALSY; CEREBRAL BLOOD-FLOW; PARKINSONS-DISEASE; HUMAN-BRAIN; BASAL GANGLIA; ENDOGENOUS DOPAMINE; GLUCOSE-UTILIZATION; NUCLEUS-ACCUMBENS; BINDING-SITES;
Keywords:
[F-18]N-METHYLSPIROPERIDOL; 2-DEOXY-2-[F-18]FLUORO-D-GLUCOSE; DRUG DEPENDENCE; BRAIN GLUCOSE METABOLISM; DOPAMINE RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
80
Recensione:
Indirizzi per estratti:
Citazione:
N.D. Volkow et al., "DECREASED DOPAMINE-D(2) RECEPTOR AVAILABILITY IS ASSOCIATED WITH REDUCED FRONTAL METABOLISM IN COCAINE ABUSERS", Synapse, 14(2), 1993, pp. 169-177

Abstract

Decreased dopaminergic function has been postulated to underlie cocaine addiction. To examine the possibility that dysfunction of brain regions subserved by the dopamine system could promote cocaine self-administration, positron emission tomography and a dual-tracer approach wasused to examine dopamine D2 receptor availability and regional brain-glucose metabolism in cocaine abusers. When compared to normal controls, cocaine abusers showed significant decreases in dopamine D2 receptor availability which persisted 3-4 months after detoxification. Decreases in dopamine D2 receptor availability were associated with decreased metabolism in several regions of the frontal lobes, most markedly orbito-frontal cortex and cingulate gyri. Dopamine dysregulation of these brain areas which are involved in the channeling of drive and affectcould lead to loss of control resulting in compulsive drug-taking behavior.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 06:55:04