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Titolo:
NEUROCHEMICAL CORRELATES OF BEHAVIORAL SENSITIZATION FOLLOWING REPEATED APOMORPHINE TREATMENT - ASSESSMENT OF THE ROLE OF D(1)-DOPAMINE RECEPTOR STIMULATION
Autore:
ROWLETT JK; MATTINGLY BA; BARDO MT;
Indirizzi:
MOREHEAD STATE UNIV,DEPT PSYCHOL MOREHEAD KY 40351 UNIV KENTUCKY,DEPT PSYCHOL LEXINGTON KY 40506
Titolo Testata:
Synapse
fascicolo: 2, volume: 14, anno: 1993,
pagine: 160 - 168
SICI:
0887-4476(1993)14:2<160:NCOBSF>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINERGIC TERMINAL EXCITABILITY; VENTRAL TEGMENTAL AREA; RAT NUCLEUS-ACCUMBENS; D1 SELECTIVE AGENTS; SUBSTANTIA NIGRA; CHRONIC AMPHETAMINE; AGONISTS; AUTORECEPTORS; SENSITIVITY; SKF-38393;
Keywords:
SKF-38393; LOCOMOTOR ACTIVITY; 3,4-DIHYDROXYPHENYLALANINE (DOPA); 3,4-DIHYDROXYPHENYLACETIC ACID (DOPAC); [H-3]SCH 23390; NIGROSTRIATAL PATHWAY; MESOLIMBIC PATHWAY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
J.K. Rowlett et al., "NEUROCHEMICAL CORRELATES OF BEHAVIORAL SENSITIZATION FOLLOWING REPEATED APOMORPHINE TREATMENT - ASSESSMENT OF THE ROLE OF D(1)-DOPAMINE RECEPTOR STIMULATION", Synapse, 14(2), 1993, pp. 160-168

Abstract

Previous research has revealed a role of repeated D1 dopamine receptor stimulation in the development of behavioral sensitization to the D1/D2 agonist apomorphine. The present experiments assessed the role of repeated D1 receptor stimulation in neurochemical changes accompanyinglocomotor sensitization to apomorphine. To assess direct effects of D1 stimulation on dopamine synthesis, rats were injected with the D1 agonist SKF 38393 (8 mg/kg), followed by an injection with the 3,4-dihydroxyphenylalanine (DOPA) decarboxylase inhibitor, NSD-1015. DOPA accumulation, assessed in striatal, nucleus accumbens-olfactory tubercle (NAOT), and ventral mesencephalon (VM) tissue samples, was not affected by acute SKF 38393. In the second experiment, rats were treated with 10 daily injections of vehicle, apomorphine (5 mg/kg) or the D1 agonistSKF 38393 (8 or 16 mg/kg). Daily measures of locomotor activity demonstrated a progressive increase in the apomorphine-treated rats, but not the SKF 38393-treated rats, across the 10 days. On day 11, all rats were injected with NSD-1015 for measurement of DOPA accumulation. Dopamine synthesis was enhanced in the striatum after repeated apomorphinetreatment. In contrast, repeated SKF 38393 treatment resulted in either a small decrease or no change in DOPA accumulation in the differentbrain regions (striatum, NAOT, VM). In the third experiment, tissue levels of dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC) and [H-3]SCH23390 binding to D1 receptors were measured in rats treated with 10 daily injections of vehicle, apomorphine (5 mg/kg), or SKF 38393 (16 mg/kg). In the striatum and NAOT, none of the repeated drug treatments had an effect on DOPAC or dopamine levels. In the VM, DOPAC levels wereenhanced following repeated apomorphine, but not repeated SKF 38393, whereas dopamine levels were not affected by either drug treatment. D1binding was not altered by the repeated drug treatments. Since repeated D1 stimulation by SKF 38393 did not produce the same alterations indopamine synthesis and DOPAC levels as repeated apomorphine, the neurochemical effects accompanying locomotor sensitization to apomorphine probably are not mediated by D1 receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:18:31