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Titolo:
A METHOD FOR RAPID-DETERMINATION OF ZOTEPINE BY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY
Autore:
TANAKA O; KONDO T; KANEKO S; MIHARA K; OTANI K; TOKINAGA N;
Indirizzi:
HIROSAKI UNIV,SCH MED,DEPT NEUROPSYCHIAT HIROSAKI AOMORI 036 JAPAN HIROSAKI UNIV,SCH MED,DEPT NEUROPSYCHIAT HIROSAKI AOMORI 036 JAPAN
Titolo Testata:
Therapeutic drug monitoring
fascicolo: 3, volume: 18, anno: 1996,
pagine: 294 - 296
SICI:
0163-4356(1996)18:3<294:AMFROZ>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOUBLE-BLIND TRIAL; HALOPERIDOL;
Keywords:
ZOTEPINE; SOLID-PHASE EXTRACTION; GAS CHROMATOGRAPHY MASS SPECTROMETRY; PHARMACOKINETICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
7
Recensione:
Indirizzi per estratti:
Citazione:
O. Tanaka et al., "A METHOD FOR RAPID-DETERMINATION OF ZOTEPINE BY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY", Therapeutic drug monitoring, 18(3), 1996, pp. 294-296

Abstract

A rapid and sensitive method using solid-phase extraction and gas chromatography-mass spectrometry (GC-MS) has been developed for the determination of zotepine (ZTP). an atypical neuroleptic, in human plasma. The detection limit of ZTP was 1 mu g/L. Standard curves over the concentration range from 2.5 to 100 mu g/L had a good linearity. Intraassay variability ranged from 2.2 to 3.3% and interassay variability from 3.5 to 6.6% at the concentration range of 5-75 mu g/L. Our preliminarydata of single-dose kinetics of ZTP by using this method suggested that the peak time and elimination half-life was much longer than previously reported, and that there appeared to be a second peak after 10-12h of ZTP administration, indicating the possibility of the presence of enterohepatic recirculation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:05:25