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Titolo:
THE CHARACTERIZATION AND LOCALIZATION OF THE MOUSE THYMOPOIETIN LAMINA-ASSOCIATED POLYPEPTIDE-2 GENE AND ITS ALTERNATIVELY SPLICED PRODUCTS
Autore:
BERGER R; THEODOR L; SHOHAM J; GOKKEL E; BROKSIMONI F; AVRAHAM KB; COPELAND NG; JENKINS NA; RECHAVI G; SIMON AJ;
Indirizzi:
CHAIM SHEBA MED CTR,INST HEMATOL IL-52621 TEL HASHOMER ISRAEL CHAIM SHEBA MED CTR,INST HEMATOL IL-52621 TEL HASHOMER ISRAEL TEL AVIV UNIV,SACKLER SCH MED IL-69978 TEL AVIV ISRAEL BAR ILAN UNIV,FAC LIFE SCI RAMAT GAN ISRAEL NCI,FREDERICK CANC RES & DEV CTR,ABL BASIC RES PROGRAM,MAMMALIAN GENET LAB FREDERICK MD 21702
Titolo Testata:
PCR methods and applications
fascicolo: 5, volume: 6, anno: 1996,
pagine: 361 - 370
SICI:
1054-9803(1996)6:5<361:TCALOT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID-SEQUENCE; TRANSCRIPTION; PHOSPHORYLATION; THYMOPENTIN; CHROMOSOMES; EXPRESSION; PROTEINS; BINDING; CLONING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
R. Berger et al., "THE CHARACTERIZATION AND LOCALIZATION OF THE MOUSE THYMOPOIETIN LAMINA-ASSOCIATED POLYPEPTIDE-2 GENE AND ITS ALTERNATIVELY SPLICED PRODUCTS", PCR methods and applications, 6(5), 1996, pp. 361-370

Abstract

Thymopoietins (Tmpos) are a group of ubiquitously expressed nuclear proteins, with sequence homology to lamina-associated polypeptide 2 (LAP2). Here we report the isolation and characterization of seven mouse Tmpo mRNA transcripts named Tmpo alpha, beta, beta', gamma, epsilon, delta, and zeta. The alpha, beta, and gamma Tmpo cDNA clones are the mouse homologs of the previously characterized human alpha, beta, and gamma TMPOs, respectively, whereas Tmpo epsilon, delta, and zeta are novel cDNAs. Additionally, the mouse Tmpo gene was cloned and characterized. It is a single-copy gene organized in 10 exons spanning similar to22 kb, which encodes all of the described Tmpo cDNA sequences, located in the central region of mouse chromosome 10, The almost identical genomic organization between the human and mouse genes, and the novel alternatively spliced mouse transcripts, led us to reanalyze the human TMPO gene. The human beta-specific domain was found to be encoded by 3exons designated 6a, 6b, and 6c and not by a single exon as describedpreviously. These findings suggest that there may be more human transcripts than currently recognized, The possible involvement of the new growing family of Tmpo proteins in nuclear architecture and cell cyclecontrol is discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 07:56:37