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Titolo:
DR4 SUBTYPES AND THEIR MOLECULAR-PROPERTIES IN A POPULATION-BASED STUDY OF SWEDISH CHILDHOOD DIABETES
Autore:
SANJEEVI CB; HOOK P; LANDINOLSSON M; KOCKUM I; DAHLQUIST G; LYBRAND TP; LERNMARK A;
Indirizzi:
KAROLINSKA INST,KAROLINSKA HOSP,DEPT MOLEC MED,M300 S-17176 STOCKHOLMSWEDEN UNIV LUND HOSP,DEPT MED S-22185 LUND SWEDEN UMEA UNIV,DEPT PEDIAT S-90187 UMEA SWEDEN UMEA UNIV,DEPT EPIDEMIOL S-90187 UMEA SWEDEN UMEA UNIV,DEPT HLTH CARE RES S-90187 UMEA SWEDEN UNIV WASHINGTON,CTR BIOENGN SEATTLE WA 98195 UNIV WASHINGTON,RH WILLIAMS LAB,DEPT MED SEATTLE WA 98195
Titolo Testata:
Tissue antigens
fascicolo: 4, volume: 47, anno: 1996,
pagine: 275 - 283
SICI:
0001-2815(1996)47:4<275:DSATMI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL ALLORECOGNITION; CLASS-II ALLELES; HLA-DR; AMINO-ACID; 1ST DOMAIN; BETA-CHAIN; SOUTH INDIANS; DQ ALLELES; MELLITUS; SUSCEPTIBILITY;
Keywords:
GENETIC SUSCEPTIBILITY; HLA-DQ; HLA-DR; IDDM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
C.B. Sanjeevi et al., "DR4 SUBTYPES AND THEIR MOLECULAR-PROPERTIES IN A POPULATION-BASED STUDY OF SWEDISH CHILDHOOD DIABETES", Tissue antigens, 47(4), 1996, pp. 275-283

Abstract

The aim of this study was to determine the association between childhood insulin-dependent diabetes mellitus (IDDM) and HLA-DR4 subtypes and to test in a population-based investigation whether the DR4 association has an effect independent to that of DQ. First, HLA genotyping identified DR4 in 337/425 (79%) patients and 148/367 (40%) controls (OddsRatio 5.67; p<0.01). Second, a total of 14 DR4 subtypes were defectedby PCR and sequence specific oligo probes. Only two DR4 subtypes, DRB10401 (62% patients and 25% controls; OR 4.95, p<0.01) and *0404 (16%patients and 10% controls; OR 1.67, p<0.05) were however positively associated with the disease. These two subtypes were positively associated only when linked to DQB10302-DQA1*0301 (DQ8) (56% patients and 14% controls; OR 7.69, p<0.01; 15% patients and 10% controls; OR 1.55, p<0.05, respectively). When DRB10401 was linked to DQB1*0301-DQA1*0301(DQ7) (6% patients and 11% controls; OR 0.52, p<0.05), this DR4 subtypes was negatively associated with IDDM. Third, tests of strongest association allowed the following ranking of alleles or haplotypes: DQB10302-DQA10301 (DQ8) > DQB1*0302 > DRB1*0401 > DRB1*10404 and the association of DRB10401 has a significant effect in DQ8 positive IDDM patients. We conclude that the DR4 association with IDDM is secondary to DQ by linkage disequilibrium, which support the role of HLA-DQ as a primary genetic risk factor for IDDM.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 09:27:11