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Titolo:
ANTICYTOPLASMATIC ANTIBODY (CANCA) IN SYP HILITIC GUMMA OF THE LUNG
Autore:
WOCKEL W; HAUSSINGER K; WEIS R; MORRESIHAUF A;
Indirizzi:
LVA OBERBAYERN,ZENT KRANKENHAUS,INST PATHOL,ROBERT KOCH ALLEE 2 D-82131 GAUTING GERMANY LVA OBERBAYERN,ZENT KRANKENHAUS,PNEUMOL KLIN D-82131 GAUTING GERMANY
Titolo Testata:
Deutsche Medizinische Wochenschrift
fascicolo: 19, volume: 121, anno: 1996,
pagine: 617 - 621
Fonte:
ISI
Lingua:
GER
Soggetto:
SECONDARY SYPHILIS; WEGENERS GRANULOMATOSIS; AUTOANTIBODIES; GLOMERULONEPHRITIS; VASCULITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
W. Wockel et al., "ANTICYTOPLASMATIC ANTIBODY (CANCA) IN SYP HILITIC GUMMA OF THE LUNG", Deutsche Medizinische Wochenschrift, 121(19), 1996, pp. 617-621

Abstract

History and clinical findings: A chest radiograph was done in a 75-year-old man with cough productive of a whitish sputum. It showed round foci in the right middle and upper robes. Serum anticytoplasmic antibody (cANCA) was 1 : 160, suggesting Wegener's granulomatosis. But the pulmonary foci actually increased in size on administration of prednisolone, 10 mg daily. Investigations: As the lung biopsy was not diagnostic, a diagnostic thoracotomy with biopsy was done and the anterior segment of the right middle lobe resected. Histological examination revealed a gumma. Active syphilis was confirmed by a TPHA-Test with a titreof 1 : 40 960. Treatment and course: Antisyphilitic treatment was given for 35 days, at first 1 mega (Penicillin E daily for five days, then erythromycin, 1000 mg, for five days, a penicillin rash having occurred. Serial serology showed a continual fall of the lues and cANCA titres. Four months postoperatively the titre in the TPHA test had fallento 1 : 640, a nd was nonreactive after five yea rs. cANCA titre fell to 1 : 16 and was negative 42 weeks after resection. Conclusion: The connection between pulmonary gumma and the presence of antiplasmatic antibodies remains unclear. Inflammatory changes in the vascular wall, which occur in both Wegener's granulomatosis and tertiary syphilis, mayhave played a role.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 10:04:24