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Titolo:
EFFECTS OF SUBSTANCE-P ON MEDIAL VESTIBULAR NUCLEUS NEURONS IN GUINEA-PIG BRAIN-STEM SLICES
Autore:
VIBERT N; SERAFIN M; VIDAL PP; MUHLETHALER M;
Indirizzi:
COLL FRANCE,CNRS,UMR C9950,LPPA,15 RUE ECOLE MED F-75270 PARIS 06 FRANCE CTR MED UNIV GENEVA,DEPT PHYSIOL CH-1211 GENEVA 4 SWITZERLAND
Titolo Testata:
European journal of neuroscience
fascicolo: 5, volume: 8, anno: 1996,
pagine: 1030 - 1036
SICI:
0953-816X(1996)8:5<1030:EOSOMV>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; DORSAL HORN NEURONS; SIGNAL-TRANSDUCTION MECHANISMS; INTRINSIC MEMBRANE-PROPERTIES; EXCITATORY AMINO-ACIDS; LOCUS-CERULEUS NEURONS; SELECTIVE AGONISTS; TACHYKININ RECEPTORS; STEM SLICES; RAT;
Keywords:
TACHYKININS; NK1 RECEPTORS; INTRACELLULAR RECORDINGS; PRIMARY VESTIBULAR AFFERENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
N. Vibert et al., "EFFECTS OF SUBSTANCE-P ON MEDIAL VESTIBULAR NUCLEUS NEURONS IN GUINEA-PIG BRAIN-STEM SLICES", European journal of neuroscience, 8(5), 1996, pp. 1030-1036

Abstract

The undecapeptide substance P (SP) has been recently implicated in the control of vestibular function. In particular, it seems to be co-localized with glutamate in approximately half of the primary vestibular afferents in mammals. Using intracellular recordings in guinea-pig brainstem slices, we have investigated the effects of SP and of several agonists of the three known tachykinin receptor subtypes (NK1, NK2 and NK3) on the three main types (A, B and B-LTS) of guinea-pig medial vestibular nucleus neurons (MVNn) that we had previously described. SP could induce two distinct kinds of effects on all types of MVNn. Whereasaround half of them were depolarized and had their membrane resistance increased by SP, similar to 10% of all MVNn were in contrast hyperpolarized and inhibited while their membrane resistance was decreased. Both responses persisted under conditions of blockade of synaptic transmission, and were thus due to the activation of postsynaptic binding sites. The SP-induced membrane depolarization could not be reproduced with any one of the specific agonists of the three tachykinin receptor subtypes, nor was it blocked by the specific NK1 receptor antagonists GR 82334 and CP 99994. This effect might therefore be due to the activation of a new, pharmacologically distinct, 'NK1-like' receptor. Only the hyperpolarizing effects, which were in contrast mimicked by the specific NK1 receptor agonists GR 73632 and [Sar(9), Met (O-2)(11)]-SP, would be mediated by the few typical NK1 receptors which have been demonstrated in the medial vestibular nucleus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 20:19:38