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Titolo:
RECEPTOR STATUS VARIATION IN PRIMARY BREAST-CANCER AND SUBSEQUENT ACCESSIBLE RELAPSE
Autore:
CORADINI D; ORIANA S; DITTO A; BRESCIANI G; DIFRONZO G;
Indirizzi:
IST NAZL TUMORI,VIA VENEZIAN 1 I-20133 MILAN ITALY CNR,CTR STUDIO PATOL CELLULARE I-20133 MILAN ITALY
Titolo Testata:
International journal of oncology
fascicolo: 5, volume: 8, anno: 1996,
pagine: 997 - 1002
SICI:
1019-6439(1996)8:5<997:RSVIPB>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGESTERONE RECEPTORS; INDIVIDUAL PATIENTS; ESTROGEN-RECEPTORS; ENDOCRINE THERAPY; SURVIVAL; DISEASE; MULTIPLE; TUMOR; ESTRADIOL; ASSAYS;
Keywords:
BREAST CANCER; PRIMARY TUMOR; SEQUENTIAL DETERMINATIONS; STEROID RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
D. Coradini et al., "RECEPTOR STATUS VARIATION IN PRIMARY BREAST-CANCER AND SUBSEQUENT ACCESSIBLE RELAPSE", International journal of oncology, 8(5), 1996, pp. 997-1002

Abstract

To better understand the prognostic relevance of change in steroid receptor status, during the clinical course of breast cancer, we analysed the variation of estrogen and progesterone receptor (ER, PgR) statusin a series of 532 primary tumors and metachronous accessible recurrences in individual patients. A more consistent variation was observed in patients with a receptor-positive primary (ER(+) or PgR(+)) than inthose with a receptor-negative tumor (ER(-) or PgR(-)). Forty-four percent of PgR(+) and 24% of ER(+) tumors became negative, whereas only 20% of ER(-) or PgR(-) became positive. The changes were independent of tumor stage and menopausal status. However, steroid receptor variation appeared to be related to the interval between the primary tumor and relapse. In fact, the changes from ER(+) to ER(-) were more frequentin patients with a disease-free survival of less than 1 year, whereaschanges from ER(-) to ER(+) occurred more often in patients with a disease-free survival of more than 3 years. Moreover, we observed a decrease in the number of ER(+) tumors following hormone treatment and a decrease in ER(-) tumors following chemotherapy. However, such variations did not reach statistical significance. Irrespective of the type ofadjuvant therapy, the presence of at least one receptor (in particular, PgR) in the metachronous lesion was correlated with a long median time to relapse and to death. Our results confirmed the predictive relevance of receptor status of the primary lesion on relapse and survivaland suggest the predictive relevance of receptor status of the metachronous lesion on post-relapse survival.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 20:00:41