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Titolo:
HUMAN HERPESVIRUS-8 DNA-SEQUENCES IN HUMAN IMMUNODEFICIENCY VIRUS-NEGATIVE ANGIOIMMUNOBLASTIC LYMPHADENOPATHY AND BENIGN LYMPHADENOPATHY WITH GIANT GERMINAL CENTER HYPERPLASIA AND INCREASED VASCULARITY
Autore:
LUPPI M; BAROZZI P; MAIORANA A; ARTUSI T; TROVATO R; MARASCA R; SAVARINO M; CECCHERININELLI L; TORELLI G;
Indirizzi:
POLICLIN MODENA,DIPARTIMENTO SCI MED,SEZ EMATOL,VIA POZZO 71 I-41100 MODENA ITALY UNIV MODENA,DEPT MED SCI,SECT HAEMATOL I-41100 MODENA ITALY UNIV MODENA,DEPT PATHOL I-41100 MODENA ITALY UNIV PISA,DEPT BIOMED,SECT VIROL I-56100 PISA ITALY
Titolo Testata:
Blood
fascicolo: 9, volume: 87, anno: 1996,
pagine: 3903 - 3909
SICI:
0006-4971(1996)87:9<3903:HHDIHI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; LYMPHOPROLIFERATIVE DISORDERS; DYSPROTEINEMIA; LYMPHOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
M. Luppi et al., "HUMAN HERPESVIRUS-8 DNA-SEQUENCES IN HUMAN IMMUNODEFICIENCY VIRUS-NEGATIVE ANGIOIMMUNOBLASTIC LYMPHADENOPATHY AND BENIGN LYMPHADENOPATHY WITH GIANT GERMINAL CENTER HYPERPLASIA AND INCREASED VASCULARITY", Blood, 87(9), 1996, pp. 3903-3909

Abstract

Human herpesvirus-8 (HHV-8) DNA sequences have been reported to be strictly associated not only with various forms of Kaposi's sarcoma but also with an unusual subgroup of acquired immunodeficiency syndrome (AIDS)-related B-cell lymphomas. A possible relation of this putative virus also with multicentric Castleman's disease (MCD) has been recentlysuggested. We used polymerase chain reaction to look for the presenceof HHV-8 sequences in a well characterized series of benign, atypical, and malignant lymphoid tissues from 45 Hodgkin's disease and 43 non-Hodgkin's lymphoma (NHL) cases, as well as from 5 MCD, 15 angioimmunoblastic lymphadenopathy (AILD), and 23 benign lymphadenopathy cases. Among the 38 AIDS-related lymphoid lesions, only 1 NHL and 1 persistent generalized lymphadenopathy (PGL) case were positive. Furthermore, among the 92 non-AIDS-related lymphoproliferative disorders, HHV-8 sequences were detected in 3 classic AILD cases and in 4 reactive lymphadenopathies. Six of 9 HHV-8 positive lymphoid lesions (1 NHL, 1 PGL, 1 AILD, and 3 reactive lymphadenopathy cases) were also positive for Epstein-Barr viral sequences. The four human immunodeficiency virus (HIV) negative lymphadenopathies positive for HHV-8 sequences showed an almostidentical histology, characterized by a predominantly follicular lesion, with giant germinal center hyperplasia, and increased vascularity,resembling HIV-related lymphadenopathy and MCD. Our results, while providing the first evidence of the presence of HHV-8 sequences in AILD cases, suggest a possible association of these herpesviral sequences with a distinct hystologic type of non-neoplastic lymphadenopathy, not associated with other common herpes infections. (C) 1996 by The American Society of Hematology.

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Documento generato il 03/12/20 alle ore 21:40:50