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Titolo:
REGULATION OF THE AMINOLEVULINATE SYNTHASE GENE IN THE SYRIAN-HAMSTERHARDERIAN-GLAND - CHANGES DURING DEVELOPMENT AND CIRCADIAN-RHYTHM ANDROLE OF SOME HORMONES
Autore:
RODRIGUEZ C; KOTLER M; ANTOLIN I; SAINZ RM; MENENDEZPELAEZ A;
Indirizzi:
FAC MED,DEPT MORFOL & BIOL CELULAR,JULIAN CLAVERIA S-N E-33006 OVIEDOSPAIN
Titolo Testata:
Microscopy research and technique
fascicolo: 1, volume: 34, anno: 1996,
pagine: 65 - 70
SICI:
1059-910X(1996)34:1<65:ROTASG>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ERYTHROID 5-AMINOLEVULINATE SYNTHASE; FEMALE GOLDEN-HAMSTER; MESSENGER-RNA LEVELS; PORPHYRIN CONTENT; MESOCRICETUS-AURATUS; LIGHTING CONDITIONS; THYROID-HORMONES; SEX-DIFFERENCES; PINEAL-GLAND; MELATONIN;
Keywords:
ALV-S MESSENGER-RNA; ESTROUS CYCLE; AGING; TESTOSTERONE; HCG; PROGESTERONE; MELATONIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
C. Rodriguez et al., "REGULATION OF THE AMINOLEVULINATE SYNTHASE GENE IN THE SYRIAN-HAMSTERHARDERIAN-GLAND - CHANGES DURING DEVELOPMENT AND CIRCADIAN-RHYTHM ANDROLE OF SOME HORMONES", Microscopy research and technique, 34(1), 1996, pp. 65-70

Abstract

The Syrian hamster Harderian gland has been advocated as a model to study the porphyrin biosynthetic pathway, since it shows by far the highest porphyrin concentration known to date. Another particular characteristic is the sexual dimorphism at both the morphological and the biochemical levels. We found a variation in the ALV-S (aminolevulinate synthase) gene expression according to sex, with females exhibiting muchhigher mRNA levels than do males. After castration, ALV-S mRNA rose considerably in males, this increase being inhibited by darkness or treatment with melatonin. Treatment with hCG or progesterone did not varythe ALV-S mRNA levels in females. Castrated males, however, showed a much larger increase when they were treated with hCG. No variations have been found in the expression of the ALV-S gene in female HG throughout the estrous cycle. During development, males and females showed similar ALV-S mRNA levels until they were 20 days old. Afterwards, they started showing gender-associated differences. In females, ALV-S mRNA levels rose during the first 3 months of life, and thereafter they decreased progressively with aging. A circadian rhythm has been found in the gene expression of ALV-S mRNA in females, showing very low levels in the morning and reaching a peak during the first hours of darkness. It was an endogenous rhythm, probably regulated at the transcriptional level. It is proposed that the light-dark period duration modulates this rhythm through the suprachiasmatic nucleus which in turn acts on the pineal secretion of melatonin that regulates ALV-S gene expression. (C) 1996 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 17:26:13