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Titolo:
INFLUENCE OF ANTIHYPERTENSIVE THERAPY WITH CILAZAPRIL AND HYDROCHLOROTHIAZIDE ON THE STIFFNESS OF THE AORTA
Autore:
BREITHAUPTGROGLER K; LESCHINGER M; BELZ GG; BUTZER R; ERB K; DEMEY C; SINN W;
Indirizzi:
ZENTRUM KARDIOVASK PHARMAKOL,MATHILDENSTR 8 D-55116 MAINZ GERMANY CTR CARDIOVASC PHARMACOL MAINZ WIESBADEN MAINZ GERMANY UNIV FRANKFURT,CTR PHYSIOL W-6000 FRANKFURT GERMANY INST SPECIAL CARDIOVASC DIAGNOST & RES ADVICE MOSSAUTAL GERMANY
Titolo Testata:
Cardiovascular drugs and therapy
fascicolo: 1, volume: 10, anno: 1996,
pagine: 49 - 57
SICI:
0920-3206(1996)10:1<49:IOATWC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING-ENZYME-INHIBITOR; CORONARY-ARTERY DISEASE; PULSE-WAVE-VELOCITY; HUMAN HYPERTENSION; BLOOD-PRESSURE; NONINVASIVE TECHNIQUES; CALCIUM ANTAGONISM; DOPPLER ULTRASOUND; ELASTIC PROPERTIES; ASCENDING AORTA;
Keywords:
AORTIC STIFFNESS; ARTERIAL DISTENSIBILITY; PULSE WAVE VELOCITY; WINDKESSEL FUNCTION; CILAZAPRIL; HYDROCHLOROTHIAZIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
K. Breithauptgrogler et al., "INFLUENCE OF ANTIHYPERTENSIVE THERAPY WITH CILAZAPRIL AND HYDROCHLOROTHIAZIDE ON THE STIFFNESS OF THE AORTA", Cardiovascular drugs and therapy, 10(1), 1996, pp. 49-57

Abstract

The purpose of this study was to examine the effects of the angiotensin-converting enzyme (ACE) inhibitor cilazapril on the elastic properties of the aorta. A standard diuretic antihypertensive drug, hydrochlorothiazide, served for comparisons. Increased aortic stiffness leads to a reduction of the buffering windkessel function and is a major component in the pathophysiology of systolic hypertension, inducing an increase in left ventricular afterload and arterial pulsatile stress as well as a decrease in the subendocardial blood supply. Stiffness of arteries increases with age and blood pressure, and depends on the functional elastic structures of the aortic wall. ACE inhibitors have been shown to directly influence elastic properties of peripheral arteries. Seventeen patients with mild to moderate essential hypertension (age 45-67 years) were treated for 3 months double-blind randomized with either cilazapril (C) 5 mg daily (n = 9) or hydrochlorothiazide (HCTZ) 25mg daily (n = 8). Aortic elastic properties were noninvasively assessed by measurement of pulse wave velocity along the aorta at rest and during isometric handgrip stress. Accelerated pulse wave velocity indicates elevated arterial stiffness and vice versa. A pressure standardized index of aortic cross-sectional distensibility (2 m) was calculatedfrom arterial mean pressure and pulse wave velocity. Compared with pretreatment values, both therapies significantly reduced blood pressureand pulse wave velocity at rest (C: 9.4 +/- 0.9 vs. 7.7 +/- 0.7 m/sec; HCTZ: 8.9 +/- 0.3 vs. 7.8 +/- 0.4 m/sec; means +/- SEM p < 0.05). During isometric stress only C showed a significant decrease in pulse wave velocity (C: 11.3 +/- 0.8 vs. 9.1 +/- 0.8 m/sec; HCTZ: 9.9 +/- 0.5 vs. 9.0 +/- 0.5 m/sec; means +/- SEM p < 0.05). The index 2m at rest and during handgrip increased significantly (p < 0.05) after C but not after HCTZ. With cilazapril we obtained steeper slopes for the treatment-induced reductions in blood pressure and pulse wave velocity for both rest and handgrip stress values. Correlation of the data at rest and during stress revealed a direct relationship between blood pressure and pulse wave velocity. HCTZ linearly extended the relation observed before treatment toward lower values of blood pressure and corresponding pulse wave velocity without changing the relation per se. Cilazapril, in contrast, moved the relation between these variables and decelerated the pulse wave velocities to a greater extent than would have been expected from the corresponding blood pressure reduction (delta approximately 1 m/sec). These results in patients with mild to moderate essential hypertension support the idea that ACE inhibitors, in additionto reducing blood pressure, mag exert an additional hemodynamic effect in improving the elastic properties of the aorta.

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Documento generato il 19/09/20 alle ore 15:12:34